Diversity related Neuro-AIDS and Mental Health Research

多样性相关的神经艾滋病和心理健康研究

• 批准号: 7288054
• 负责人: AVINDRA NATH
• 金额: $ 23.84万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-16 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288054
• 关键词: AIDS Dementia Complex; AIDS diagnosis; AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Affect; African American; Age; Anti-Retroviral Agents; Area; Arts; Attention; CD4 Lymphocyte Count; Caucasians; Caucasoid Race; Centers for Disease Control and Prevention (U.S.); Child; Chinese People; Cognition Disorders; Collaborations; Country; Cultural Diversity; Data; Diagnosis; Disease; Environment; Epidemiologic Studies; Ethics; Ethnic group; Face; Female Adolescents; Filipino; Genetic; Geographic Factor; Goals; HIV; HIV Infections; Hawaii; Hawaiian population; Health Surveys; Heterosexuals; Hispanic AIDS; Hispanics; Impaired cognition; Infection; Intravenous Drug Abuse; Island; Japanese Population; Laboratories; Longitudinal Studies; Medical Surveillance; Mental Health; Mentors; Minor; Minority; Minority Groups; Modality; Motor; Nervous system structure; Neurologic; Nomads; Pathogenesis; Patients; Persons; Pharmacogenetics; Population; Population Heterogeneity; Postdoctoral Fellow; Predisposition; Prevalence; Principal Investigator; Psyche structure; Publishing; Puerto Rico; Purpose; Rate; Relative Risks; Reporting; Research; Research Personnel; Rosa; Science; Scientific Advances and Accomplishments; Scientist; Stable Populations; Students; Talents; Technology; Time; Training; Translational Research; United States; Universities; Viral Load result; Week; Woman; base; disability; follow-up; health disparity; innovation; member; men; neuropsychiatry; programs; social; teacher; therapy development; transmission process

DESCRIPTION (provided by applicant): HIV infection of the nervous system frequently results in neuropsychiatric complications and is a major cause of disability in the HIV infected population. To date there is no effective treatment for the illness and is further complicated by the fact that this infection disproportionately affects racial and ethnic minorities. Several barriers need to be overcome if we want to make a significant impact on this illness. Not only do we need to understand the social and cultural diversities that impact the spread of this infection and our ability to treat these populations, but even the pathophysiological studies and development of treatment strategies need to pay close attention to racial and ethic diversity. Few published studies suggest that host genetic factors may be critical in determining host susceptibility to HIV dementia and as the field of pharmacogenetics is evolving, it is also becoming clear that treatment strategies also need to be tailored based of host genetics. Another major barrier is the lack of scientists from racial and ethnic minority groups in the field of NeuroAIDS research. We have taken several steps to address each of these issues. We have developed a program on the premise that the principal barrier to diversity in science is not a lack of talent, but rather a lack of opportunity. We devised a course in NeuroAIDS that not only uses the state of the art technology and the best teachers and researchers in the field, but the subject content is specifically geared to address each of the issues and point out areas of research that are needed to accomplish these goals. This 12 week course will be webcast so that students will be able to take it from anywhere in the country and yet actively engage in a discussion with the teachers. This didactic course will be followed up with a laboratory based project for a duration of 3-6 months for select students to generate preliminary data for a application focused on neuro-AIDS. To accomplish these goals, we will exploit our existing collaborations with University of Puerto Rico and University of Hawaii to train students and postdoctoral fellows from racial and ethnic minorities. We will also train researchers at Johns Hopkins University in issues that face HIV infected populations of racial and ethnic minorities.

描述（由申请人提供）：神经系统的艾滋病毒感染经常导致神经精神并发症，是艾滋病毒感染人群残疾的主要原因。迄今为止，尚无有效的疾病治疗方法，这种感染对种族和少数族裔的影响不成比例，这一事实更加复杂。如果我们想对这种疾病产生重大影响，则需要克服一些障碍。我们不仅需要了解影响这种感染传播以及我们治疗这些人群的能力的社会和文化多样性，而且即使是病理生理研究和治疗策略的发展，也需要密切关注种族和道德多样性。很少有研究的研究表明，宿主遗传因素对于确定宿主对HIV痴呆的敏感性可能至关重要，并且随着药物遗传学领域的发展，也很明显，还需要根据宿主遗传学来定制治疗策略。另一个主要障碍是神经助长研究领域的种族和少数民族群体缺乏科学家。我们已经采取了几个步骤来解决这些问题。我们已经制定了一个计划，即前提是科学多元化的主要障碍不是缺乏才能，而是缺乏机会。我们设计了一门神经辅助的课程，该课程不仅使用了最先进的技术和该领域的最好的教师和研究人员，而且专门针对问题的内容来解决每个问题，并指出实现这些目标所需的研究领域。这12周的课程将进行网络广播，以便学生能够从该国任何地方进行访问，并积极与老师进行讨论。该教学课程将在一个基于实验室的项目中进行3-6个月的时间，以便某些学生生成针对神经辅助的应用程序的初步数据。为了实现这些目标，我们将利用与波多黎各大学和夏威夷大学的现有合作，以培训来自种族和少数民族的学生和博士后研究员。我们还将在约翰·霍普金斯大学（Johns Hopkins University）的研究人员培训研究人员面临艾滋病毒感染种族和少数民族的人群。