COBRE: UNE MED CTR: P1: ROLE OF DESMOSOMES IN ORAL SQUAMOUS CELL CARCINOMA

COBRE：UNE MED CTR：P1：桥粒在口腔鳞状细胞癌中的作用

• 批准号: 7171283
• 负责人: JAMES K WAHL
• 金额: $ 21.6万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171283
• 关键词: biological signal transduction; carcinogenesis; health science research support

DESCRIPTION (provided by applicant): This COBRE application proposes to establish a Center for Cellular Signaling that will augment and strengthen the research capacity within the Dental Schools in Nebraska. The Center will include scientists from three nearby research universities in Nebraska: University of Nebraska Medical Center, University of Nebraska at Lincoln and Creighton University. The objectives of the Center are 1) to expand the current focus on cellular signaling, with a concentration on its role in tumorigenesis; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. To accomplish these goals we will create the necessary infrastructure, which will consist of 1) An organized Center that includes a dedicated director aided by an assistant, an Administrative Advisory Council, a group of committed mentors, an External Advisory Council, and a group of talented project leaders; 2) A collection of inter-related research projects focused on cellular signaling; and 3) A program of development, designed to enhance and sustain the Center, that will include a seminar program, graduate student stipends and a seed grant program. We have strong support from all three institutions and a plan in place to sustain the program when the COBRE funding expires. The PI and mentors involved in this project are committed to developing a culture of mentoring within the Colleges of Dentistry in Nebraska. In addition, the collaborative environment resulting from the formation of the Center will enhance the research infrastructure within Nebraska's Dental Schools. Thus, the chances we will meet all our goals are very high.

描述（由申请人提供）： 该脚底应用建议建立一个细胞信号中心，该中心将增强内布拉斯加州牙科学校内的研究能力。该中心将包括来自内布拉斯加州附近三所研究大学的科学家：内布拉斯加州大学医学中心，内布拉斯加州大学林肯大学和克雷顿大学。中心的目标是1）扩大当前对细胞信号传导的关注，并集中于其在肿瘤发生中的作用； 2）提高内布拉斯加州牙科学校的研究概况，最终的目标是将其纳入美国国立卫生研究院的顶级牙科学校；而且，最重要的是，3）为有前途的年轻教师的发展做出贡献，以便他们将成为科学界的杰出成员，这是由大量NIH资助，重要的手稿的发表，评论小组的服务和邀请在全国范围内讲话的。 为了实现这些目标，我们将创建必要的基础设施，该基础设施由1）一个有组织的中心组成，其中包括由助手，行政咨询委员会，一群忠诚的导师，外部咨询委员会，外部咨询委员会和一群才华横溢的项目领导者提供的敬业董事； 2）集中于细胞信号传导的相互关联研究项目的集合； 3）旨在增强和维持中心的开发计划，其中包括研讨会计划，研究生津贴和种子赠款计划。 我们得到了所有三个机构的大力支持，并制定了一项计划，以维持该计划时，当鞋底资金到期。参与该项目的PI和导师致力于在内布拉斯加州的牙科学院发展一种指导文化。此外，由中心形成而产生的协作环境将增强内布拉斯加牙科学校内的研究基础设施。因此，我们实现所有目标的机会很高。