MARSHALL U COBRE: SKI AND SNO TRANSCRIPTION FACTORS IN TESTICULAR CANCERS

MARSHALL U COBRE：睾丸癌中的滑雪和滑雪转录因子

• 批准号: 7171407
• 负责人: LAURA L RICHARDSON
• 金额: $ 22.19万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171407
• 关键词: clinical research; neoplasm /cancer; transcription factor

DESCRIPTION (provided by applicant): Marshall University in the final stages of the development of the Edwards Cancer Center. Through the generosity of the Edwards family, funds are being used to construct a cancer center building and to establish an endowment. The new Cancer Building is currently being constructed and will be primarily a diagnostic and treatment facility. In light of these developments we are establishing a Cancer Research Center (CRC) that will complement and interdigitate with the clinical component of the Edwards Cancer Center. As part of this CRC we are proposing a COBRE entitled "Transcription Factors in Cancer" The COBRE consists of four projects and three cores. Project 1: "Beta catenin function and retinoic acid in melanoma", Beverly, Delidow, Principal Investigator will build on preliminary findings that retinoic acd reduces nuclear content and function of beta-catenin in melanoma to explore the consequences of this multifunctional protein in progression of human melanoma. Project 2: "Retinoids, NF-kB and Mn-SOD in Neuroblastoma", Kelley Kiningham, PI. will explore the hypothesis that Mn-SOD is required for retinoid-induced differentiation and that reactive oxygen species are involved in signaling. Project 3 "Sap, a potential zebrafish oncogene", Maiyon Park, Principal Investigator investigates the exciting finding that overexpression of sap in zebrafish embryos leads to tumor formation and will determine if a human oncogene counterpart is present is some human tumors. Project 4: "The role of Ski/Sno in testicular cancer", Laura Richardson, PI, deals with overexpression and function of this transcription factor in testicular cancer. These projects are supported by Administrative, Imaging and Genomics Cores. All projects deal with retinoids or its signaling pathway in a least a portion of their research. Thus there will be a great deal of interaction regarding common assays and reagents. This critical mass of investigators working on a common scientific theme with multiple interactions, supported by strong cores provides a unique opportunity for both career development of COBRE investigators and development of a nationally competitive research center.

描述（由申请人提供）： 马歇尔大学在爱德华兹癌症中心发展的最后阶段。通过爱德华兹家族的慷慨，资金被用于建造癌症中心建筑并建立捐赠。目前正在建造新的癌症建筑，主要是诊断和治疗设施。鉴于这些发展，我们正在建立一个癌症研究中心（CRC），该中心将与爱德华兹癌症中心的临床成分进行补充并互相互。作为此CRC的一部分，我们提出了一个杂种，标题为“癌症中的转录因子”，该鞋底由四个项目和三个核心组成。项目1：“黑色素瘤中的β链球菌功能和视黄酸性”，首席研究员贝弗利（Beverly）将基于初步发现，即视黄氨基酸ACD降低了黑色素瘤中β-catenin的核含量和功能，以探索这种多功能蛋白在人类黑素瘤进展中的多功能蛋白。项目2：“神经母细胞瘤中的类视感，NF-KB和MN-SOD”，PI Kelley Kiningham。将探讨以下假设，即维生素类似于类维生素类似的分化需要MN-SOD，并且活性氧与信号传导有关。项目3“ SAP，潜在的斑马鱼癌基因”，Maiyon Park，首席研究者调查了令人兴奋的发现，即斑马鱼胚胎中SAP的过表达会导致肿瘤形成，并将确定人类癌基因对应物是否存在。项目4：“滑雪/SNO在睾丸癌中的作用”，PI劳拉·理查森（Laura Richardson），涉及该转录因子在睾丸癌中的过表达和功能。这些项目得到了行政，成像和基因组学核心的支持。所有项目都在其研究的很大一部分研究中涉及类视感或其信号通路。因此，关于常见测定和试剂将有很多互动。在强大的核心支持下，批量研究了具有多种互动的共同科学主题的批判群体为鞋底研究人员的职业发展和全国竞争性研究中心的发展提供了独特的机会。