DE PEDIATRIC COBRE: MOLECULAR MECHANISMS IN PELIZAEUS MERZBACHER DISEASE

DE PEDIATRIC COBRE：Pelizaeus Merzbacher 病的分子机制

• 批准号: 7171397
• 负责人: Grace M. Hobson
• 金额: $ 14.88万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171397
• 关键词: clinical research; human subject; pediatrics

DESCRIPTION (provided by applicant): The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This will be accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research Institute/Alfred I. duPont Hospital for Children, to study pediatric diseases, therapy and prevention. The Nemours Research Institute is located on the grounds of the Alfred I. duPont Hospital in Wilmington, Delaware, where a close relationship is maintained between the two facilities. The new research center, The Center for Pediatric Research (CPR), will focus on three aims: 1) To develop a Center that will support basic and applied research on pediatric disorders by providing the infrastructure to train basic and physician scientists (target investigators) in their quest to become independent investigators who can successfully procure outside funding for their research programs. The CPR will foster the development of these junior scientists by providing the money, resources and core lab services for the projects; 2) To develop an integrated mentoring program to enrich the training of the target investigators. Established investigators with proven histories in scientific research and grant acquisition will provide scientific and academic direction to the target investigators, thus fostering the advancement of this core group of scientists to build a stronger research program, ensuring the long-term expansion of biomedical research in Delaware; and 3) To develop a translational research program within the CPR that enriches the interface between clinical and basic research by developing clinically relevant systems for basic research as well as scientifically sound approaches to clinical research. We will recruit investigators with experience in clinical and applied basic research to form a multidisciplinary research group studying pediatric diseases, providing additional research programs and infrastructure for the long-term development of an NIH-funded Translational CPR at the Nemours Research Institute. The COBRE program proposed herein wilt have two long-term benefits: 1) the number of NIH-competitive researchers in Delaware will increase; 2) the CPR will be poised to apply for a other Center grants which are few in Delaware.

描述（由申请人提供）： 这项杂种提案的主要目标是增加特拉华州活跃的，NIH资助的生物医学研究人员的数量。这将是通过Nemours研究所/Alfred I. Dupont儿童医院的多学科研究人员的努力来实现的，以研究儿科疾病，治疗和预防。 Nemours研究所位于特拉华州威尔明顿的Alfred I. Dupont医院的地面上，在这两个设施之间保持了密切的关系。新的研究中心，小儿研究中心（CPR），将重点关注三个目标：1）开发一个中心，通过为基础架构提供基础设施来培训基本和医师科学家（目标研究人员），以寻求成功为他们的研究计划提供资金的独立研究人员，以支持小儿疾病的基本和应用研究。 CPR将通过为项目提供资金，资源和核心实验室服务来促进这些初级科学家的发展； 2）制定综合指导计划，以丰富目标研究人员的培训。在科学研究和赠款中拥有良好历史的成熟研究人员将为目标研究人员提供科学和学术方向，从而促进了这一核心科学家群体的发展，以建立更强大的研究计划，以确保在特拉华州生物医学研究的长期扩张； 3）通过开发用于基础研究的临床相关系统以及科学的临床研究方法，开发了CPR中的转化研究计划，以丰富临床和基础研究之间的界面。我们将招募具有临床和应用基础研究经验的研究者，以组建研究小儿疾病的多学科研究小组，为Nemours研究所的NIH资助的转化CPR的长期发展提供其他研究计划和基础设施。本文提出的毛cre计划具有两个长期的好处：1）特拉华州的NIH竞争力研究人员的数量将增加； 2）CPR准备申请其他在特拉华州很少的中心补助金。