UKY DENTAL COBRE: ORAL INFECTIONS: COX-2 AND 12/15-L0IN ATHEROSCLEROSIS

英国 DENTAL COBRE：口腔感染：COX-2 和 12/15-L0IN 动脉粥样硬化

• 批准号: 7171342
• 负责人: Charles David Loftin
• 金额: $ 25.69万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171342
• 关键词: clinical research; human subject; oral bacteria; periodontitis

DESCRIPTION (provided by applicant): The objectives of the Center for the Biologic Basis of Oral/Systemic Diseases (CBBOSD) are: RESEARCH: To develop a better understanding of the biologic principles that underpin the observed linkages of chronic oral infections and inflammation with systemic disease sequelae; and TRAINING: To use this research focus as a platform to develop promising young investigators in oral health sciences and enhance their competitiveness for external funding, including NIH grant support. We will accomplish these objectives by: Organizing a cadre of established, funded scientists to examine crucial questions related to oral and systemic health linkages, Providing young research faculty with opportunities for interdisciplinary training in oral health sciences and systemic disease, Mentoring young faculty in research projects focused on oral infections, host responses, and systemic disease that will lead to success as independent NIH-funded researchers, Developing and supporting core facilities and resources to optimize the research enterprise of the CBBOSD faculty, Facilitating pilot projects, as well as intra- and inter-university collaborations among CBBOSD faculty, and other researchers at the University of Kentucky, Strategic hiring of new faculty to complement existing strengths to contribute to a critical mass of funded investigators in the biology of oral-systemic diseases. To address this need, we have organized the research activities and leadership of the CBBOSD into 2 broad thematic areas. These thematic areas will incorporate 6 research projects that are integrated with respect to underlying concepts, methodologies, and availability of biological specimens. THEMATIC AREA 1: Oral infections: Translational studies of hostparasite interactions; Project 1: Oral Infections and HIV Recrudescence; Project 2: Oral Infections: Inflammation, Lipid Metabolism, and Atherosclerosis; Project 3: Oral Infections: Genomic Analysis of Host Responses to Polyrnicrobial Infections;. THEMATIC AREA 2: Oral infections: Clinical implications for systemic disease; Project 4: Oral Infections: Impact on Gestational Diabetes; Project 5: Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses; Project 6: Oral Infections: Viral/Bacterial Interactions in Chronic Diseases. These research projects are integral to the goals of the CBBOSD because they focus on critical questions of the biology of chronic oral infections and contribution to alterations in systemic health. The overall focus of the CBBOSD is diverse to enable this interdisciplinary research team to: (i) address the myriad of challenges in understanding critical parameters of the interplay between infections and disease in the oral cavity, and (ii) use the available expertise of senior faculty at UK with experience in mentoring young investigators. Thus, junior investigators will be integrated into research projects with established, funded faculty who use state-of-the-art cellular and molecular approaches to explore the biologic basis of this relationship. The breadth of science and varied senior research expertise assures that the CBBOSD will provide opportunities for many junior investigators, who will have the capability to interact within this nurturing environment. The outcomes of this mentored, nurturing structure will enhance the maturation of oral health research at UK, through the College of Dentistry, and synergize in expanding NIH-funded research in the Commonwealth of Kentucky.

描述（由申请人提供）： 口腔/全身疾病中心（CBBOSD）的生物基础中心的目标是：研究：为了更好地理解生物学原理，这些原理是基于慢性口腔感染和与全身性疾病后遗症的慢性口腔感染和炎症联系在一起的联系；和培训：将这项研究重点作为一个平台，以培养口腔健康科学领域的年轻研究人员，并增强其在外部资金中的竞争力，包括NIH赠款支持。我们将通过以下方式实现这些目标：组织成熟的，有资助的科学家研究与口腔和系统性健康联系相关的关键问题，为年轻的研究教师提供了在口腔健康科学和系统性疾病中进行跨学科培训的机会，指导年轻的教师在研究项目中的研究项目和发展方面的疾病，并将其作为NIH的疾病发展，并将其用于疾病，并领导NIH-FUND，并将其领导为NIH-FUND，并将其领导。为了优化CBBOSD教师的研究企业，促进了试点项目，以及CBBOSD教师之间的内部和大学间合作，以及肯塔基大学的其他研究人员，战略性地雇用新的教师，以补充现有的现有实力，以补充现有的现有基金会的生物学杂货，或者是基金会的研究人员，或者是基金会的调查人员。为了满足这一需求，我们将CBBOSD的研究活动和领导组织组织成两个广泛的主题领域。这些主题领域将结合6个有关基本概念，方法和生物标本可用性的研究项目。主题区域1：口腔感染：宿主帕斯特相互作用的翻译研究；项目1：口腔感染和HIV复发；项目2：口腔感染：炎症，脂质代谢和动脉粥样硬化；项目3：口腔感染：对多虫感染的宿主反应的基因组分析；主题区域2：口腔感染：对全身性疾病的临床意义；项目4：口腔感染：对妊娠糖尿病的影响；项目5：口腔感染：局部和系统性炎症反应的饮食调节；项目6：口腔感染：慢性疾病中的病毒/细菌相互作用。这些研究项目是CBBOSD的目标不可或缺的一部分，因为它们集中于慢性口腔感染生物学的关键问题以及对系统健康改变的贡献。 CBBOSD的总体重点是使该跨学科研究团队能够：（i）在理解口腔中感染与疾病之间相互作用的关键参数方面所面临的无数挑战，（ii）使用英国高级教师的可用专业知识，并在指导年轻调查人员方面经验丰富。因此，初级研究人员将与已建立的，资助的教师一起纳入研究项目，他们使用最先进的细胞和分子方法来探索这种关系的生物学基础。科学的广度和多样化的高级研究专业知识确保CBBOSD将为许多初级调查人员提供机会，他们将有能力在这种养育环境中进行互动。这种指导的，培养的结构的结果将通过牙科学院增强英国口腔健康研究的成熟，并协同扩大肯塔基州联邦NIH资助的研究。