Identifying patient invariant parameters for diagnosis using terahertz sensing

使用太赫兹传感识别患者不变参数进行诊断

• 批准号: 2869381
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869381
• 关键词: Identifying; patient; invariant; parameters; diagnosis

Terahertz (1012 Hz, THz) pulsed imaging is a new technique with high resolution and has only emerged recently as a potential new clinical tool for medical imaging. It is a totally non-destructive and non-ionising imaging modality as the average power of the pulse for producing the radiation is as small as 100 nW. The radiation produced is focused onto the sample of interest and then detected coherently. A point measurement is analogous to an ultrasound A-scan. Reflections off different layers are used to determine the structure at various depths. THz light is very sensitive to hydrogen bonds. By Fourier transforming the time-domain data, useful spectroscopic information can also be revealed. Potential applications range from security imaging to medical diagnosis, but the analysis and instrumentation needs to be tailored for each application investigated. THz light can be generated and detected using photoconductive antennas. The useable frequency range of a THz system depends on the photoconductive devices as well as other factors such as optical alignment.We have developed a handheld THz probe that has been used in the first clinical trials of their kind at the University hospital in Coventry. The aim of this project is to take and analyse patient and volunteer data a view to developing classification algorithms for skin conditions. For example, it may be possible to use THz imaging to detect early stages of skin cancer, or the lateral extent of tumours that are beneath the skin's surface, and not yet visible. This project will give the student experience in Optics, coding, signal processing and machine learning.

Terahertz（1012 Hz，THz）脉冲成像是一种具有高分辨率的新技术，最近才成为一种潜在的医学成像临床工具。这是一种完全无损和非离子化成像方式，因为产生辐射的脉冲的平均功率小至100 nW。产生的辐射集中在感兴趣的样本上，然后连贯地检测到。点测量类似于超声A扫描。不同层的反射用于确定各个深度的结构。 THZ光对氢键非常敏感。通过转换时间域数据的傅立叶，也可以揭示有用的光谱信息。潜在应用从安全成像到医学诊断范围，但是需要针对所研究的每个应用程序量身定制分析和仪器。可以使用光电自动天线生成和检测到THZ光。 THZ系统的可用频率范围取决于光电传入设备以及其他因素，例如光学对齐。我们开发了一种手持式THZ探针，该探针已在考文文大学的大学医院的第一次临床试验中使用。该项目的目的是吸收和分析患者和志愿者数据来开发针对皮肤状况的分类算法。例如，可能可以使用THZ成像检测皮肤癌的早期阶段，或者是皮肤表面下方肿瘤的横向程度，尚不可见。该项目将使学生在光学，编码，信号处理和机器学习方面的体验。