Mitochondrial metabolism as a target for human metabolites of dietary anthocyanins

线粒体代谢作为人类膳食花青素代谢物的靶标

基本信息

批准号：
2869083
负责人：
金额：
--
依托单位：
University of East Anglia
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2869083
关键词：
Mitochondrial metabolism target human metabolites

项目摘要

The research is expected to generate evidence that specific anthocyanin metabolites have beneficial effects on mitochondrial metabolism and may protect mitochondria from becoming dysfunctional, for example when exposed to supra-optimal nutrient levels (e.g., during the post-prandial phase or in at-risk groups such as those diagnosed as pre-diabetic or metabolic syndrome). This will be of interest to health professionals including dieticians/clinicians who provide dietary advice to people who are at-risk of developing metabolic disease. The findings will also be of interest to nutraceutical companies who are seeking to develop and market products that target metabolic dysfunction. The identification of specific anthocyanin human metabolites that cause beneficial changes in mitochondrial function / energy metabolism in this project can underpin future R&D to identify the best sources of these metabolites (which may or may not be anthocyanins) and subsequently the development of new nutraceutical products. The data could also be used to develop pre-/pro-/syn-biotics that can increase production of these metabolites in the gut in the longer term this research could be used to underpin changes in dietary advice from policy makers if these invitro observations were backed up by data from properly designed and well controlled human dietary intervention studies.

预计该研究将产生证据，表明特定的花青素代谢对线粒体代谢具有有益的作用，并可能保护线粒体免于功能失调，例如，当暴露于远端的养分水平上（例如，在野外阶段或在野生阶段或诸如诸如诊断性诊断型诊断或接受过的临床中的较高风险的组中）。这将引起卫生专业人员的兴趣，包括营养师/临床医生，他们为患有代谢性疾病的危险患者提供饮食建议。这些发现也将引起人们寻求开发和销售针对代谢功能障碍的产品的营养公司。在该项目中导致线粒体功能 /能量代谢的有益变化的特定花道蛋白人类代谢产物的鉴定可以支持未来的研发，以识别这些代谢物的最佳来源（可能是或可能不是花种子素），并随后开发新的营养产品。该数据还可以用于开发前/pro-/pro-/synbiotics，可以从长远来看，可以在肠道中增加这些代谢产物的产生，如果这些invitro观察得到了经过精心设计和良好控制的人类饮食干预研究的数据，则可以将这些研究的饮食建议构成饮食建议的变化。