Laser Spectrometry Development for Isotopic Analysis in Environmental and Medical Applications

环境和医疗应用中同位素分析的激光光谱测定法开发

• 批准号: 2764502
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2764502
• 关键词: Laser; Spectrometry; Development; Isotopic; Analysis

will investigate the potential towards IR-absorption laser spectrometry for traceability of low-level very high precision measurements of stable isotopes and radiocarbon in carbon dioxide and methane, relevant for environmental monitoring and drug discovery applications. Carbon-14 in particular is an ideal radioactive tracer for many processes and this project will culminate in the development of these measurements. (1) As the UK transitions towards 'net zero carbon', new and improved methods of verifying industrial emissions and atmospheric composition will be required. Atmospheric C-14 measurements allow for the estimation of the fossil-fuel fraction of CO2 and CH4. (2) C-14 as a tracer is vital for the rapid and cost-effective development of drugs, notably for the treatment of cancer. It is used in the early efficacy stage of drug development to understand how the human body will handle the drug in terms of the absorption, distribution, metabolism and elimination (ADME).

将研究红外吸收激光光谱法对二氧化碳和甲烷中稳定同位素和放射性碳的低水平超高精度测量的可追溯性的潜力，与环境监测和药物发现应用相关。 Carbon-14 尤其是许多过程的理想放射性示踪剂，该项目将在这些测量的开发中达到顶峰。 (1) 随着英国向“净零碳”过渡，将需要新的和改进的方法来验证工业排放和大气成分。大气 C-14 测量可以估算 CO2 和 CH4 的化石燃料比例。 (2) C-14 作为示踪剂对于药物的快速且经济有效的开发至关重要，特别是对于癌症的治疗。它用于药物开发的早期疗效阶段，以了解人体如何处理药物的吸收、分布、代谢和消除（ADME）。