CHARACTERIZATION OF VIRAL FIBROBLAST GROWTH FACTOR

病毒成纤维细胞生长因子的表征

• 批准号: 7170519
• 负责人: A. LORENA PASSARELLI
• 金额: $ 7.29万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-03 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170519
• 关键词: antibiotics; clinical research; microorganism; microorganism disease chemotherapy; peptides; pharmacology

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three PhD granting institutions in Kansas, (KU at Lawrence and the KU School of Medicine in Kansas City, and K State University) to become more competitive for securing NIH grant support. This will be achieved by creation of a strong mentoring body (comprised of Dr. Narayan and other established, NIH-funded senior faculty at the three institutions), establishment of committees of internal and outside advisors to the COBRE program, institutionalization of monthly seminar and data presentation meetings, and an annual meeting dedicated to factors important in preparation of NIH grant applications. Three cores, one administrative, and two technical will be established to expedite the research program. The COBRE will receive extensive institutional support in the form of FTEs, new research equipment, and space. The research theme is centered on mechanisms inhibiting replication of pathogenic microbes, with the long-term goal of controlling infectious diseases important in human health. Studies will be focused on identification of genes and gene products that have a seminal role in microbial replication. To find inhibitors for these proteins, we will link up with the COBRE program at KU/Lawrence to exploit resources in combinatorial chemistry and high-throughput screens for inhibitors of the proteins in question. We will also exploit more biological approaches using core support with phage display and aptamer technology, which will be shared among investigators. Further, we will establish core facilities in X-ray crystallography and fermentation for the isolation and determination of the 3-D structures of the proteins, which will be useful for development of potential drugs. Six junior faculty members, two of whom are experienced X-ray crystallographers, have been selected for support for two to three years. The projects of currently selected faculty were based on scientific merit, potential for complementary interaction with other projects, and potential for exploiting the core resources of both COBRE programs. Projects of new junior faculty will be selected and awards made upon recommendation of the internal advisory committee. A portion of the COBRE fund will be used to enhance faculty recruitment packages.

描述（申请人提供）：要求提供五年的支持 创建一项教师发展计划，该计划将使初级教师参与 在堪萨斯州的三个博士学位授予机构的研究中（劳伦斯的KU 以及堪萨斯城的KU医学院和K州立大学） 获得确保NIH赠款支持的竞争力。这将被实现 通过创建强大的指导机构（由Narayan博士和其他 在三个机构中成立，由NIH资助的高级教师）， 建立内部和外部顾问委员 计划，每月研讨会的制度化和数据演示 会议和年度会议，致力于准备准备的因素 NIH赠款申请。三个核心，一个行政和两个技术 将建立以加快研究计划的速度。毛绒将收到 FTE，新研究设备，新的研究设备形式的广泛机构支持 和空间。研究主题以抑制机制为中心 病原微生物的复制，其长期目标是控制 传染病在人类健康中很重要。研究将集中在 鉴定具有精确作用的基因和基因产物 微生物复制。为了找到这些蛋白质的抑制剂，我们将链接 借助KU/Lawrence的Cobre计划，可以利用合并的资源 用于蛋白质抑制剂的化学和高通量筛选 问题。我们还将使用核心支持来利用更多的生物学方法 通过噬菌体显示和适体技术，将在其中共享 调查人员。此外，我们将在X射线中建立核心设施 晶体学和发酵，用于隔离和测定 蛋白质的3-D结构，这对于开发 潜在药物。六名初级教职员工，其中两个经验丰富 X射线晶体学家已被选为两到三个 年。目前选择的教师的项目是基于科学的 优点，与其他项目互补互动的潜力，以及 利用这两个毛cre计划的核心资源的潜力。项目 将选择新的初级教师，并根据建议 内部咨询委员会。一部分毛茸茸的基金将用于 增强教师招聘包。