Steroid modulation of a rhythmic vocal pattern generator

节奏声音模式发生器的类固醇调制

• 批准号: 7233261
• 负责人: MICHELE C ZEE
• 金额: $ 5.04万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-16 至 2008-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7233261
• 关键词: Androgens; Cells; Communication; Courtship; Development; Electric Capacitance; Estrogens; Fire - disasters; Frequencies; Genomics; Goals; Hormonal; In Vitro; Ions; Lead; Mediating; Membrane; Membrane Potentials; Motor; Motor Neurons; Motor output; Neurons; Nuclear Hormone Receptors; Pacemakers; Pattern; Preparation; Production; Property; Research; Resistance; Rest; Sex Characteristics; Shapes; Social Environment; Spinal; Stereotyping; Steroids; Testing; Time; Vertebrates; Work; hindbrain; in vivo; neural circuit; non-genomic; response; sound; steroid hormone; teleost; teleost fish; vocalization

DESCRIPTION (provided by applicant): Vocal communication is essential for courtship among many vertebrates. Studies in teleost fish provide considerable evidence that vocalizations are controlled by distinct neural circuits which show seasonal and sex differences in response to circulating levels of steroid hormones. Prior in vivo work has also shown that steroids can induce rapid changes in 'fictive vocalization.' This application will focus on the teleost vocal pattern generator located in the hindbrain-spinal region since it provides the simplest vertebrate preparation for determining how steroid hormones modulate the properties of pacemaker and motor neurons that lead to vocalization within a social context. An electrophysiological approach will be used to describe steroid-induced changes in vocal patterning at the level of intrinsic membrane properties of these identified neurons with the development of an in vitro preparation. The central goal of this research is to understand how steroid hormones modulate the production of highly stereotyped sounds for vocal communication by mediating changes in neuronal membrane properties via both rapid, non-genomic mechanisms and longer acting mechanisms mediated by nuclear hormone receptors.

描述（由申请人提供）：声音交流对于许多脊椎动物的求爱至关重要。在硬骨鱼中的研究提供了大量证据，表明发声是由明显的神经回路控制的，这些神经回路显示出对循环水平类固醇激素的季节性和性别差异。先前的体内工作还表明，类固醇可以引起“虚构发声”的快速变化。该应用程序将重点放在后脑脊柱区域的硬骨料声模式发生器上，因为它为确定类固醇激素如何调节起搏器和运动神经元的特性，从而提供了最简单的脊椎动物准备，从而导致社交环境中发声。电生理方法将用于描述类固醇诱导的人声模式变化，并在这些鉴定出的神经元的内在膜特性水平上随着体外制剂的发展而形成。这项研究的核心目的是了解类固醇激素如何通过快速，非基因组机制和核激素受体介导的较长的作用机制来调节神经元膜特性的变化来调节声音通信的高度刻板印象。