University of Texas Specialized Program in Acute Stroke

德克萨斯大学急性中风专业项目

• 批准号: 7227990
• 负责人: JAMES C GROTTA
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227990
• 关键词: clinical research; human subject; patient oriented research; stroke; stroke therapy

DESCRIPTION: (abstract provided by the applicant): The past 20 years of stroke research have shown that acute stroke is a treatable disease but reversibility of damage is tightly time dependent. It is possible to find exciting treatment strategies in the laboratory, but difficult to design and carry out clinical research to translate them into clinical benefit. Even when effective therapy is demonstrated, there are unexpectedly huge impediments to having it adopted and widely available. Given the massive public health problem of stroke in our aging population, these conundrums demand our attention. They are the foci of the UT Stroke Program and the SPOTRIAS PA. The thematic model of our Stroke Program is to develop improved treatment of acute stroke by 1) laboratory investigation into the biology of stroke, 2) clinical investigation of new therapies based on these laboratory studies, and 3) assessment of outcome and improved application of effective therapies. This Program Project has three broad Specific Aims: 1. Development of effective new acute stroke therapies through clinical research projects based on biological principles of ischemic injury learned in the laboratory. We will describe four planned Phase 1 or 2 Clinical trials of novel acute interventions; caffeinol for neuroprotection, the thrombin inhibitor argatroban to enhance reperfusion after TPA, ultrasound to augment clot lysis after TPA, and constraint induced movement therapy to amplify recovery. These projects require the multidisciplinary involvement of EMS, Emergency Medicine, Radiology, Critical Care, Ultrasound, and Rehabilitation. 2. Application of more efficient and widespread acute stroke treatment by improving the organization of local and regional stroke centers using cutting-edge telemedicine technology, and evaluation of a novel middle-school educational initiative to help solve the problem of inadequate public knowledge. 3. Development of Clinical, Statistical, Human Tissue, and Training "Cores" that will facilitate the accomplishment of Specific Aims # 1 and 2. These cores will also provide important new resources for fellowship training.

描述：（申请人提供的摘要）： 过去20年的中风研究表明，急性中风是一种可治疗的疾病，但 损害的可逆性与时间紧密相关。可以在实验室找到令人兴奋的治疗策略，但很难设计和进行临床研究以将其转化为临床益处。即使证明了有效的疗法，也出乎意料的是，采用并广泛使用它。鉴于我们老龄化的人口中遇到了巨大的中风问题，这些难题需要我们的关注。它们是UT中风计划和Spotrias PA的焦点。我们中风计划的主题模型是通过1）基于这些实验室研究的新疗法的临床研究来开发改进急性中风的治疗方法，2）对新疗法进行临床研究，3）评估结果并改善了有效疗法的应用。该计划项目具有三个广泛的特定目标：1。通过基于在实验室中学到的缺血性损伤的生物学原理的临床研究项目开发有效的新急性中风疗法。我们将描述四个计划的1或2期新型急性干预措施的临床试验； Caffeinol用于神经保护作用，凝血酶抑制剂Argatroban可在TPA后增强再灌注，超声以增强TPA后的凝块溶解，并约束诱导运动疗法以扩大恢复。这些项目需要EMS，急诊医学，放射学，重症监护，超声和康复的多学科参与。 2。通过改善更有效和广泛的急性中风治疗的应用 使用尖端的远程远程医疗技术组织本地和区域中风中心的组织， 并评估一项新颖的中学教育计划，以帮助解决问题 公众知识不足。 3。开发临床，统计，人体组织和训练“核心”，这些核心将有助于完成特定目标＃1和2。这些核心还将为奖学金培训提供重要的新资源。