MALARIA IMMUNOLOGY AND GENETICS IN THE AMAZON (MIGIA) PROJECT

亚马逊 (MIGIA) 项目中的疟疾免疫学和遗传学

• 批准号: 7349085
• 负责人: BILLIE B DAVISON
• 金额: $ 3.1万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349085
• 关键词: MALARIA; IMMUNOLOGY; GENETICS; AMAZON; MIGIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased susceptibility of pregnant women to malaria and its adverse effects on the fetus are well established. However the epidemiologic factors and immunologic mechanisms associated with the complications of malaria in pregnancy are poorly understood. The Department of Loreto, Peru has experienced a re-emergence of malaria due to P. vivax and P. falciparum during the last 15 years. A high frequency of asymptomatic infections caused by both these Plasmodium species has been reported in the general population of this region indicating that despite low transmission, protective immunity to clinical malaria has developed. In a study investigating malaria infection in pregnant women living in the Amazon lowlands of Iquitos, Peru it was hypothesized that this acquired immunity is antibody mediated and protects against severe maternal and fetal complications of malaria infection during pregnancy, including placental malaria, infant low birth weight and maternal anemia. One of the goals of this project addressed in its third specific aim was to assess the frequency of both current and past placental malaria infection by histopathologic detection of malaria parasites and hemozoin deposition in placental tissue sections from women in Iquitoes. Once evaluated, the placental histopathologic findings were compared in women with evidence of malaria infection during pregnancy (postitive blood smears or PCR) to that from women with no evidence of infection during pregnancy. The goal was to determine if there is a relationship between the placental findings and malaria infection during pregnancy, antibody titers, and maternal and fetal outcomes. The Division of Pathology prepared and stained sections from placental biopsy tissue collected in Peru and Dr Davison assisted the doctoral student, Falgunee Parekh with the histopathologic evaluations. The results are being evaluated at this time and the results will be published in 2006.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。孕妇对疟疾的易感性增加及其对胎儿的不利影响是众所周知的。然而，人们对与妊娠期疟疾并发症相关的流行病学因素和免疫机制知之甚少。过去 15 年里，秘鲁洛雷托省因间日疟和恶性疟再次出现疟疾。据报道，该地区普通人群中由这两种疟原虫引起的无症状感染发生率很高，这表明尽管传播率较低，但对临床疟疾的保护性免疫力已经形成。 在一项调查秘鲁伊基托斯亚马逊低地孕妇疟疾感染的研究中，假设这种获得性免疫力是抗体介导的，可以预防怀孕期间疟疾感染的严重母婴并发症，包括胎盘疟疾、婴儿低出生体重以及产妇贫血。该项目在其第三个具体目标中提出的目标之一是通过组织病理学检测伊基托斯妇女胎盘组织切片中的疟疾寄生虫和疟原虫色素沉积来评估当前和过去胎盘疟疾感染的频率。评估后，将妊娠期间有疟疾感染证据（阳性血涂片或 PCR）的女性的胎盘组织病理学结果与妊娠期间没有感染证据的女性的胎盘组织病理学结果进行比较。目的是确定胎盘检查结果与妊娠期间疟疾感染、抗体滴度以及母婴结局之间是否存在关系。病理学部门从秘鲁收集的胎盘活检组织中制备切片并进行染色，Davison 博士协助博士生 Falgunee Parekh 进行组织病理学评估。目前正在评估结果，结果将于 2006 年公布。