Growth Factor Coated Sutures for Improved Tendons Repair

生长因子涂层缝合线可改善肌腱修复

• 批准号: 7106723
• 负责人: PAUL T HAMILTON
• 金额: $ 20.3万
• 依托单位: AFFINERGY ,INC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-28 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106723
• 关键词: growth factor; peptides; surgery material /equipment; tendons; tissues

DESCRIPTION (provided by applicant): Tendon injuries are quite common and the frequency of these injuries is expected to rise as the population ages, yet continues to remain active. Long periods of immobilization and rehabilitation are required because tendon healing is a relatively slow process. Innovations that can shorten this time period by improving healing rates and increasing the strength of repair tissue will be of great value for patients and society. Earlier activity is believed to promote better return of function, accelerated healing, and improved quality of tendon repair tissue. However, this early motion and activity cannot be at the cost of increasing gapping of the two tendon ends or even frank re-rupture. Attempts have been made with ultrasound, mechanical stimulation, and growth factors to increase healing rates to provide enough mechanical strength to allow patients to start activity that will put load on the healing tendons, while still protecting the integrity of the initial suture repair. The goal of this Phase I SBIR proposal is to validate an IFBM approach to bind bioactive molecules such as growth factors to non-absorbable polyester suture (Ethibond, Ethicon, Inc.), which is commonly used in many types of tendon repair. We present a novel approach to create target-specific modular peptides that bind bioactive agents (growth factors, cells, etc.) to synthetic biocompatible surfaces (matrix polymer, metal, etc.). These specifying and grafting biopolymers are termed "interfacial biomaterials" (IFBMs). A bi-functional IFBM has the unique advantages of a) providing requisite surface binding specificity, b) comprising robust chemistry for broad-based applications and c) offering capacity to specify a wide range of associated or independent biological activities onto a single scaffold or surface. Cartilage derived morphogenetic proteins (CDMP) -1, -2 and -3 (also known as BMP -14, -13, and -12) have recently been shown to be involved in tendon development and healing. We believe that binding growth factors such as those of the CDMP family to suture with IFBM technology could significantly improve the clinical outcomes after surgical repair of tendons by increasing healing rates and by improving the quality of the repair tissue.

描述（由申请人提供）：肌腱损伤非常普遍，随着人口年龄的增长，这些损伤的频率预计会增加，但仍保持活跃。需要长时间的固定和康复，因为肌腱愈合是一个相对较慢的过程。通过提高愈合率并提高修复组织强度可以缩短这段时间的创新对患者和社会具有很高的价值。据信较早的活动可以促进功能的更好回报，加速愈合和肌腱修复组织的提高。但是，这种早期运动和活动不能取决于增加两个肌腱末端甚至坦率重新爆发的损失。尝试通过超声，机械刺激和生长因子进行了尝试，以提高愈合率，以提供足够的机械强度，以使患者能够开始活动，从而使康复肌腱负载，同时仍保护初始缝合修复的完整性。该阶段I SBIR提案的目的是验证IFBM结合生物活性分子（例如生长因子）与不可吸收的聚酯缝合线（Ethibond，Ethicon，Inc。）结合的方法，该方法通常在许多类型的肌腱修复中使用。我们提出了一种新的方法，以创建目标特异性的模块化肽，该模块化肽将生物活性剂（生长因子，细胞等）与合成生物相容性表面（矩阵聚合物，金属等）结合在一起。这些指定和嫁接的生物聚合物称为“界面生物材料”（IFBMS）。双功能IFBM具有a）提供必要的表面结合特异性的独特优势，b）包括针对广泛应用的鲁棒化学，c）提供在单个支架或表面上指定广泛相关或独立的生物活性的能力。最近已证明软骨衍生的形态发生蛋白（CDMP）-1，-2和-3（也称为BMP -14，-13和-12）最近被证明与肌腱发育和愈合有关。我们认为，具有IFBM技术缝合的结合生长因子（例如CDMP家族的生长因子）可以通过提高愈合率和提高修复组织的质量来显着改善肌腱手术修复后的临床结局。