Moffitt Aging and Cancer Program Development

莫菲特老龄化和癌症项目开发

• 批准号: 7273599
• 负责人: PAUL B JACOBSEN
• 金额: $ 29.56万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273599
• 关键词: Adult; Aging; Applications Grants; Appointment; Area; Award; Basic Science; Biology of Aging; Cancer Center; Cancer Center Planning Grant; Cancer Center Support Grant Application; Cancer Control; Cancer Patient; Cancer Research Project; Clinical; Clinical Oncology; Clinical Research; Collaborations; Communities; Comorbidity; Comprehensive Cancer Center; Conduct Clinical Trials; Development; Development Plans; Educational Activities; Educational workshop; Elderly; Ensure; Faculty; Florida; Fostering; Funding; Future; Geographic Locations; Goals; Health; Immunology; Investigation; Lead; Leadership; Letters; Location; Malignant Neoplasms; Measurement; Medical; Mission; National Cancer Institute; Numbers; Outcome; Pain; Palliative Care; Population; Prevention; Prevention strategy; Program Development; Reporting; Research; Research Institute; Research Personnel; Resource Sharing; Risk; Scientist; Social Aspects of Cancer; Therapeutic; Translating; Treatment Efficacy; Universities; anticancer research; base; design; end of life care; interest; knowledge base; member; molecular oncology; programs; response

DESCRIPTION: (Applicant's Description) This Planning and Development (P20) Grant application, submitted in response to RFA CA-030504, seeks funding to develop an Aging and Cancer Research Program at the H. Lee Moffitt Cancer Center and Research Institute, an NCI-designated Comprehensive Cancer Center. The Moffitt Cancer Center is ideally suited to develop such a program based on: 1) its location in a geographic region with a large population of older adults; 2) the relatively large number of older adults receiving treatment at the center; 3) the existence for many years of a Senior Adult Oncology Clinical Program at the center that has provided initial opportunities to develop aging and cancer research collaborations; 4) the presence of numerous cancer center members interested in expanding their focus to include issues related to aging; and 5) the presence of numerous aging researchers at the University of South Florida (where all cancer center members hold their faculty appointments) interested in expanding their focus to include issues related to cancer. Funds provided by this award would be used to develop research related to five aging and cancer themes identified in a recent NINNCI Workshop Report: Treatment Efficacy and Tolerance, Effects of Comorbidity and Cancer, Psychosocial Issues and Medical Effects, Palliative Care, End-of-Life Care, and Pain Relief, and the Biology of Aging and Cancer. Toward this end, funds would be used to support promising pilot research in each of these areas as well as a variety of planning and educational activities designed to foster additional collaborations among aging and cancer researchers. Funds also would be used to hire new faculty in basic science and clinical research whose backgrounds and expertise bridge areas identified as promising for collaboration. In addition, funds would be used to establish a new shared resource in Health Outcomes Measurement that is likely to be used by numerous funded investigators conducting aging and cancer research, and to enhance existing shared resources providing biostatistical support and support for the conduct of clinical trials. Letters of commitment included in the application document the strong support of the senior leadership of the Moffitt Cancer Center for this effort. Consistent with the goals of the RFA, receipt of this award is expected to lead to the development of an Aging and Cancer Research Program that will merit incorporation into future Cancer Center Support Grant applications by the Moffitt Cancer Center.

描述：（申请人的描述）此规划和发展 (P20) 拨款申请是针对 RFA CA-030504 提交的，寻求资助在 H. Lee Moffitt 癌症中心和研究所 (NCI-指定综合癌症中心。 莫菲特癌症中心非常适合开发这样的计划，因为：1）其位于老年人口众多的地理区域； 2）在中心接受治疗的老年人数量较多； 3) 该中心多年来一直存在高级成人肿瘤学临床项目，为发展衰老和癌症研究合作提供了初步机会； 4) 许多癌症中心成员有兴趣将其关注范围扩大到与衰老相关的问题； 5) 南佛罗里达大学（所有癌症中心成员均担任教职）的众多老龄化研究人员有兴趣将其关注范围扩大到与癌症相关的问题。该奖项提供的资金将用于开展与最近 NINNCI 研讨会报告中确定的五个衰老和癌症主题相关的研究：治疗效果和耐受性、合并症和癌症的影响、心理社会问题和医疗影响、姑息治疗、临终关怀生活护理、疼痛缓解、衰老和癌症生物学。 为此，资金将用于支持每个领域有前景的试点研究，以及旨在促进老龄化和癌症研究人员之间更多合作的各种规划和教育活动。 资金还将用于聘请基础科学和临床研究领域的新教师，他们的背景和专业知识将被认为是有希望合作的领域。 此外，资金将用于在健康结果衡量方面建立新的共享资源，该资源可能会被众多受资助的进行衰老和癌症研究的研究人员使用，并加强现有的共享资源，为临床试验的进行提供生物统计支持和支持。申请中包含的承诺书记录了莫菲特癌症中心高层领导对此工作的大力支持。 与 RFA 的目标一致，获得该奖项预计将促进老龄化和癌症研究计划的发展，该计划将值得纳入莫菲特癌症中心未来的癌症中心支持拨款申请。

项目成果

Telomere length in myelodysplastic syndromes.

• DOI: 10.3109/10428194.2011.568648
• 发表时间: 2011-08
• 期刊: Leukemia & lymphoma
• 影响因子: 2.6
• 作者: Rollison DE;Epling-Burnette PK;Park JY;Lee JH;Park H;Jonathan K;Cole AL;Painter JS;Guerrier M;Meléndez-Santiago J;Fulp W;Komrokji R;Lancet J;List AF
• 通讯作者: List AF