Collicular influence on auditory thalamic neurons

丘脑对听觉丘脑神经元的影响

• 批准号: 7162910
• 负责人: PHILIP H SMITH
• 金额: $ 24.06万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162910
• 关键词: Area; Auditory; Aversive Stimulus; Brain; Calcium; Cells; Chemosensitization; Chromosome Pairing; Data; Dorsal; Electroencephalography; Epilepsy; Event; Extravasation; Fees; Fire - disasters; Glutamates; In Vitro; Inferior; Inferior Colliculus; L Forms; Medial; Membrane Potentials; Methods; Modeling; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Neurons; Output; Plastics; Play; Population; Publishing; Range; Rattus; Role; Sensory; Sensory Process; Shapes; Signal Transduction; Slice; Slow-Wave Sleep; Sodium; Synapses; Synaptic plasticity; Testing; Thalamic Nuclei; Thalamic structure; Thinking; Time; base; classical conditioning; conditioned fear; gamma-Aminobutyric Acid; in vivo; mossy fiber; presynaptic; receptor; research study; response; sensory stimulus; sensory system; voltage

DESCRIPTION (provided by applicant): We have shown that both excitatory (glutamatergic) and inhibitory (GABAergic) cells in the inferior colliculus (IC) project to and synapse on cells in the auditory thalamus (MGB). Our long-term objective is to understand the role of these excitatory and inhibitory IC inputs in shaping the responses of cells in the MGB. The sensory thalamus was once considered to be a simple relay center whose cells received ascending sensory information and passively sent it on to the cortex. Over the past 3 decades it has become apparent that this is not the case and that thalamic cells can function in two different response modes, "burst" and "tonic" which depend on the activation or inactivation of a voltage sensitive calcium conductance. Depending upon which mode the cell is in drastically alters their spike response to ascending excitatory synaptic messages and thus changes their input to the cortex in response to sensory stimuli (see Sherman, '01). In addition, the synchronized response of populations of thalamic cells while in the burst mode are believed to be responsible for the EEG oscillations seen during slow wave sleep and during some types of generalized epileptic seizures (see McCormick and Bal, '97). Recent evidence primarily from our lab has indicated that an added level of complexity is found in the auditory thalamus. Here 1) in contrast to other sensory thalamic nuclei, the ascending synaptic information is in the form of both excitation and inhibition 2) this ascending sensory input may be influencing auditory thalamic cells that do not necessarily display the two different response modes and 3) this ascending sensory input from the IC to some cells in the MGB may show synaptic plasticity. Thus, models of thalamic function that have been created using other sensory systems may not be applicable to the auditory thalamus. In order to better understand the similarities and/or differences in auditory thalamic processing of sensory information it is important to determine 1) how and when the excitatory and inhibitory IC inputs are active and thus influencing thalamic neurons 2) whether these inputs are influencing cells that can respond either in one mode or two and 3) whether stimulation of the collicular inputs can generate synaptic plasticity (LTP) in certain MGB cells and what mechanism of potentiation is involved. The proposed experiments will help to answer these questions.

描述（由申请人提供）：我们已经表明，下丘（IC）（IC）项目中的兴奋性（谷氨酸能）和抑制性（Gabaergic）细胞都可以在听觉丘脑（MGB）的细胞上进行突触。我们的长期目标是了解这些兴奋性和抑制性IC输入在塑造MGB中细胞反应中的作用。 感觉丘脑曾经被认为是一个简单的继电器中心，其细胞收到上升的感觉信息并被动地将其发送到皮层。在过去的三十年中，很明显，情况并非如此，丘脑细胞可以在两种不同的响应模式中起作用，即“爆发”和“滋补”，这取决于电压敏感钙电导的激活或失活。根据哪种模式，细胞处于急剧上，会大大改变其对上升兴奋性突触消息的尖峰响应，从而改变其对感觉刺激的输入对皮质的反应（请参阅Sherman，'01）。此外，据信，在爆发模式下，丘脑细胞种群的同步反应是导致慢波睡眠期间和某些类型的广泛性癫痫发作期间看到的脑电图振荡（见McCormick和Bal，97）。最新的证据主要来自我们的实验室，表明在听觉丘脑中发现了增加的复杂程度。这里1）与其他感觉丘脑核相反，上升的突触信息是激发和抑制作用的形式。2）此上升感觉输入可能会影响听觉丘脑细胞，这些丘脑丘脑细胞不一定显示两种不同的响应模式，而3）从IC到MGB中的某些细胞中的某些细胞可能显示出MGB中的某些细胞。因此，使用其他感觉系统创建的丘脑功能模型可能不适用于听觉丘脑。 为了更好地理解感觉信息的听觉丘脑处理的相似性和/或差异，重要的是要确定1）兴奋性和抑制性IC输入如何以及何时有效，从而影响丘脑神经元2）这些输入是否在某些模式或两个和两个模化范围内都可以在某些模式下响应造成胶水的细胞，是否可以刺激造成胶水的突出型，是否可以刺激促粒细胞突出型物质。涉及增强机制。拟议的实验将有助于回答这些问题。