Neural Bases of Auditory Processing Disorders in Adults

成人听觉处理障碍的神经基础

• 批准号: 7047969
• 负责人: PATRICK C WONG
• 金额: $ 22.48万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-09 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047969
• 关键词: aging; attention; auditory cortex; belief; brain; children; clinical research; communication disorders; deafness; diagnosis; functional magnetic resonance imaging; nervous system

DESCRIPTION (provided by applicant): Auditory Processing Disorders (APD), also known as Central Auditory Processing Disorders, is characterized by deficits in processing complex verbal and nonverbal acoustic signals. The diagnosis, treatment, and even the very existence of APD are controversial. Little is known about the pathophysiology of APD. The National Institute of Deafness and Other Communication Disorders stated that much research is still needed to understand this disorder (NIH Pub. No. 01-4949, 2004). Despite the lack of evidence on many fronts, as well as difficulty with third-party payment reimbursements, individuals with APD symptoms are being diagnosed and treated everyday, and students in clinical audiology are taught to provide services to this population. This proposed research aims at building evidence for APD, with particular attention to exploring the common belief that APD is associated with neurophysiologic and possibly neuroanatomic anomalies in the central auditory nervous system. Functional Magnetic Resonance Imaging will be utilized as APD individuals process complex acoustic signals, as well as high-resolution anatomical imaging. Although APD is often discussed in children, this first research will focus on the more ontogenetically developed brain (ages 25 to 40) for ease of comparison with existing auditory fMRI data. Future experiments will include both children and adults. Specifically, the proposed research aims at investigating the following: 1) Whether neuroanatomic anomalies exist in adults diagnosed with APD based on behavioral testing, and whether it is feasible to use MRI to identify them. 2) Whether it is feasible to use MRI to identify neurophysiologic anomalies in APD adults. If so, whether APD is associated with a collection of unifying or diverse neurophysiologic anomalies.

描述（由申请人提供）：听觉处理障碍（APD），也称为中枢听觉处理障碍，其特征是处理复杂的言语和非言语声信号的缺陷。 APD 的诊断、治疗，甚至是否存在都存在争议。关于 APD 的病理生理学知之甚少。美国国家耳聋和其他沟通障碍研究所表示，仍需要进行大量研究来了解这种障碍（NIH Pub. No. 01-4949, 2004）。尽管在许多方面缺乏证据，并且第三方支付报销也存在困难，但患有 APD 症状的个人每天都在接受诊断和治疗，临床听力学的学生也被教导为这一人群提供服务。这项拟议的研究旨在为 APD 建立证据，特别关注探索 APD 与中枢听觉神经系统的神经生理学异常和可能的神经解剖学异常相关的普遍观点。功能磁共振成像将用于 APD 个体处理复杂的声学信号以及高分辨率解剖成像。尽管 APD 经常在儿童中讨论，但第一项研究将重点关注个体发育更为成熟的大脑（25 至 40 岁），以便于与现有的听觉功能磁共振成像数据进行比较。未来的实验将包括儿童和成人。具体来说，本研究旨在调查以下内容：1）基于行为测试诊断为 APD 的成年人是否存在神经解剖异常，以及使用 MRI 来识别它们是否可行。 2）使用MRI来识别APD成人的神经生理异常是否可行。如果是这样，APD 是否与一系列统一或不同的神经生理异常有关。