The Association between obesity, central adiposity and endocrine disruptors

肥胖、中心性肥胖与内分泌干扰物之间的关联

基本信息

批准号：
7037733
负责人：
ELIZABETH E HATCH
金额：
$ 20.19万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-01 至 2008-01-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The prevalence of obesity has increased several-fold over the last few decades in children, adolescents, and adults. Some evidence suggests that there has been a disproportionate increase in the level of central adiposity, which carries an even greater disease risk than peripheral fat. Changes in diet and exercise habits over the past few decades are undoubtedly linked to the current epidemic of overweight and obesity, and changes in the quality and composition of the diet may also play a role. Recently, interest has emerged in the possibility that environmental chemical contaminants may also contribute to the growing problem of obesity. Limited evidence from laboratory studies suggests that synthetic chemicals may affect obesity- related pathways by changing hormone levels or altering gene expression, but virtually no human studies have been conducted. In this proposed epidemiologic study, cross-sectional data on a sample of approximately 5000 participants, aged 6 years and older, from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) will be analyzed to determine whether blood and urine levels of environmental contaminants are associated with level of body fat. The measures of body fat to be examined include body mass index, waist circumference, subscapular skin folds, and the amount and type of body fat, estimated using dual-energy x-ray absorptiometry (DXA). The study will examine the potential adverse effects of exposure to phthalates and heavy metals as well as the possible protective effects of phytoestrogens such as genestein on total body fat and the level of central adiposity. Potentially important interactions between these environmental exposures and age, gender, various dietary factors, activity levels will also be examined. Finally, the study includes a secondary analysis that takes advantage of the repeated NHANES surveys over four decades to answer the question of whether the level of central adiposity has increased over time in separate age, race, and gender subgroups, after adjusting for increases in BMI. This study is designed to use existing data to explore the novel hypothesis that environmental contaminants may, in part, be responsible for the increasing rates of total obesity and the increases in visceral fat deposition in children and adults. The strengths of the study include its large sample size, state-of-the-art measurements of environmental contaminants from blood and urine, precise measurements of BMI, DXA-derived measures of central adiposity, and extensive information on potential confounders and effect modifiers. The study is limited by its cross-sectional nature. Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity.

描述（由申请人提供）：在过去的几十年中，在儿童，青少年和成人中，肥胖症的流行率增加了几倍。一些证据表明，中枢性肥胖水平的增加不成比例，这比外周脂肪具有更大的疾病风险。在过去的几十年中，饮食和运动习惯的变化无疑与当前超重和肥胖的流行有关，饮食的质量和成分的变化也可能起作用。最近，出现了兴趣，即环境化学污染物也可能导致肥胖的日益增长的问题。实验室研究的有限证据表明，合成化学物质可能通过改变激素水平或改变基因表达来影响肥胖相关的途径，但实际上没有进行人类研究。在这项拟议的流行病学研究中，将分析1999 - 2002年国家健康和营养检查调查（NHANES）的大约5000名参与者的样本的横截面数据（NHANES），以确定是否与体内脂肪水平相关。待检查的体内脂肪的度量包括体重指数，腰围，皮肤褶皱褶皱以及使用双能量X射线吸收测定法（DXA）估算的体内脂肪的数量和类型。该研究将检查暴露于邻苯二甲酸酯和重金属的潜在不利影响，以及植物雌激素（例如Genestein）对总体内脂肪和中央肥胖水平的保护作用。这些环境暴露与年龄，性别，各种饮食因素，活动水平之间的潜在重要相互作用也将被检查。最后，该研究包括一项二级分析，该分析利用了四十年来重复的NHANES调查，以回答以下问题，即在调整了BMI的增加后，在不同的年龄，种族和性别亚组中，中央肥胖水平是否随着时间的流逝而增加。这项研究旨在使用现有数据来探索以下新假设，即环境污染物可能部分负责总肥胖症的增加和儿童和成人内脏脂肪沉积的增加。这项研究的优势包括其大型样本量，血液和尿液中环境污染物的最新测量，BMI的精确测量，中央肥胖的衍生测量方法以及对潜在混杂因素的广泛信息和效应修饰符。该研究受其横截面性质的限制。然而，它可能为未来的流行病学研究提供重要的线索，以了解这些环境污染物对肥胖风险的影响。