Superior Cardiac MRI using Wideband SSFP at 3 Tesla

使用 3 特斯拉宽带 SSFP 进行卓越的心脏 MRI

• 批准号: 7016566
• 负责人: Krishna S Nayak
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016566
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cardiovascular imaging /visualization; clinical research; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): Cardiac magnetic resonance imaging (MRI) shows great potential but requires substantial improvements in contrast, spatial resolution, and speed. Two recent advances of particular interest are the development of balanced steady state free precession (SSFP) imaging sequences (equivalently known as True-FISP, FIESTA, or Balanced-FFE), and the development and availability of 3 Telsa clinical scanners. Both provide substantial improvements in SNR and contrast but together, 3T and SSFP are relatively incompatible for rapid high-resolution cardiac imaging. Conventional SSFP is critically limited by banding artifacts that require the use of repetition times of 3 ms or less in the heart at 3T. This limits the achievable spatial resolution, and prevents the use of time-efficient acquisition schemes to reduce scan time. The aim of this proposal is to develop and validate a new imaging technique, which we call Wideband SSFP, that uses alternating repetition times to achieve a steady-state that provides up to double the bandwidth of conventional SSFP, with comparable SNR and contrast. This bandwidth improvement allows the use of longer imaging TRs which will supporting readouts on the order of 4 ms, to enable high spatial resolution (increased readout gradient area) and high temporal resolution (using time-efficient acquisition schemes). The goal of this proposal is to fully characterize and develop Wideband SSFP and apply it to rapid high- resolution cardiac MRI at 3 Tesla. Utilizing SNR improvements from the 3T platform and from SSFP sequences to achieve higher spatial and temporal resolution directly addresses the current limitations of clinical cardiac MRI.

描述（由申请人提供）：心脏磁共振成像（MRI）具有巨大的潜力，但需要对对比度，空间分辨率和速度进行大量改进。最近特别感兴趣的两个进步是均衡稳态自由进动（SSFP）成像序列的发展（等效地称为true-fisp，嘉年华或平衡-FFE），以及3台TELSA临床扫描仪的开发和可用性。两者都提供了SNR和对比度的实质性改进，但是3T和SSFP对于快速的高分辨率心脏成像相对不相容。传统的SSFP受到束缚伪影的限制，这些伪影需要在3T的心脏中使用3毫秒或以下的重复时间。这限制了可实现的空间分辨率，并防止使用时间效率的采集方案减少扫描时间。该建议的目的是开发和验证一种新的成像技术，我们称之为宽带SSFP，该技术使用交替的重复时间来实现稳态，该稳态提供了与常规SSFP的带宽两倍，具有可比的SNR和对比度。这种带宽的改进允许使用较长的成像TRS，该TR可以支持4 ms的读数，以实现高空间分辨率（增加读取梯度区域）和高时间分辨率（使用时间效率高的采集方案）。该提案的目的是充分表征和发展宽带SSFP，并将其应用于3特斯拉的快速高分辨率心脏MRI。利用3T平台和SSFP序列的SNR改进来实现较高的空间和时间分辨率，直接解决了临床心脏MRI的当前局限性。