Admittance to measure cardiac mechanics in mice

测量小鼠心脏力学的准入

基本信息

项目摘要

DESCRIPTION (provided by applicant): Genetically altered mice provide a mechanism to define the in vivo phenotype of individual genes. This is especially relevant to genes implicated in producing myocardial diseases leading to congestive heart failure. The classic method to assess the hemodynamic phenotype in larger animals is through left ventricular (LV) pressure-volume (PV) analysis. However, determining absolute and instantaneous volume in the murine LV has been plagued by its small size and rapid heart rate. Conductance measurements offer an attractive solution to this problem by generating an instantaneous LV volume signal compatible with any myocardial size or heart rate. Unfortunately, the first generation conductance instrument generates an instantaneous conductance (volume) signal composed of blood and myocardium even at a single lower frequency. Only the blood component is desired for PV analysis. A mechanism to overcome this limitation is proposed by measuring admittance (complex conductance). Admittance is composed of both the magnitude of LV blood and myocardial conductance, and the phase angle of myocardial conductance. Traditional single frequency conductance measures only the magnitude of the conductance signal, which includes both the blood and myocardial components. Because measurable phase angle is unique to muscle, admittance offers a better method to determine and remove the instantaneous myocardial contribution to the combined LV conductance (volume) signal. The GOAL of this grant application is to develop, calibrate, and validate an INSTRUMENT to measure both the magnitude and the phase angle of the admittance signal in real time. To accomplish this goal, we will - 1) Develop both analog hardware and digital data acquisition Admittance Instruments, 2) Develop a more accurate method to derive LV volume from admittance measurements using FEM, and 3) Demonstrate that an Admittance Instrument is superior to traditional single frequency with MRI.
描述(由申请人提供):遗传改变的小鼠提供了定义单个基因体内表型的机制。这与涉及产生心肌疾病的基因尤其重要,导致充血性心力衰竭。评估较大动物血流动力学表型的经典方法是通过左心室(LV)压力卷(PV)分析。然而,确定鼠LV中的绝对和瞬时体积受到其小尺寸和快速心率的困扰。电导测量通过产生与任何心肌大小或心率兼容的瞬时LV音量信号,为该问题提供了有吸引力的解决方案。不幸的是,第一代电导仪器即使在单个较低的频率下也会产生由血液和心肌组成的瞬时电导(体积)信号。仅需要血液成分进行PV分析。通过测量入学(复杂电导)提出了克服这种限制的机制。入场率包括LV血液和心肌电导的大小以及心肌电导的相角。传统的单个频率电导仅测量电导信号的大小,其中包括血液和心肌成分。由于可测量的相角是肌肉独有的,因此入学提供了一种更好的方法来确定和去除对合并LV电导(体积)信号的瞬时心肌贡献。该赠款应用的目的是开发,校准和验证一种工具,以实时测量入学信号的幅度和相位角度。为了实现这一目标,我们将 - 1)开发模拟硬件和数字数据采集仪器,2)开发一种更准确的方法来从使用FEM的入学测量中得出LV量,而3)证明了接纳工具优于传统的单频率,使用MRI。

项目成果

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MARC David FELDMAN其他文献

MARC David FELDMAN的其他文献

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{{ truncateString('MARC David FELDMAN', 18)}}的其他基金

Transvenous Optoacoustic-Ultrasound Guided Cold Laser Wire for Crossing Coronary Chronic Total Occlusion
经静脉光声超声引导冷激光线穿越冠状动脉慢性完全闭塞
  • 批准号:
    10612422
  • 财政年份:
    2022
  • 资助金额:
    $ 18.92万
  • 项目类别:
Transvenous Optoacoustic-Ultrasound Guided Cold Laser Wire for Crossing Coronary Chronic Total Occlusion
经静脉光声超声引导冷激光线穿越冠状动脉慢性完全闭塞
  • 批准号:
    10435198
  • 财政年份:
    2022
  • 资助金额:
    $ 18.92万
  • 项目类别:
LV SV using Admittance for Hemodynamically Unstable Arrhythmia Detection
使用导纳进行 LV SV 检测血流动力学不稳定心律失常
  • 批准号:
    8887475
  • 财政年份:
    2015
  • 资助金额:
    $ 18.92万
  • 项目类别:
LV SV using Admittance for Hemodynamically Unstable Arrhythmia Detection
使用导纳进行 LV SV 检测血流动力学不稳定心律失常
  • 批准号:
    9250203
  • 财政年份:
    2015
  • 资助金额:
    $ 18.92万
  • 项目类别:
Detection of plaque based macrophages with light
用光检测基于斑块的巨噬细胞
  • 批准号:
    8394614
  • 财政年份:
    2010
  • 资助金额:
    $ 18.92万
  • 项目类别:
Detection of plaque based macrophages with light
用光检测基于斑块的巨噬细胞
  • 批准号:
    8259055
  • 财政年份:
    2010
  • 资助金额:
    $ 18.92万
  • 项目类别:
Detection of plaque based macrophages with light
用光检测基于斑块的巨噬细胞
  • 批准号:
    7930086
  • 财政年份:
    2010
  • 资助金额:
    $ 18.92万
  • 项目类别:
Detection of plaque based macrophages with light
用光检测基于斑块的巨噬细胞
  • 批准号:
    8195920
  • 财政年份:
    2010
  • 资助金额:
    $ 18.92万
  • 项目类别:
Admittance to measure cardiac mechanics in mice
测量小鼠心脏力学的准入
  • 批准号:
    7268052
  • 财政年份:
    2006
  • 资助金额:
    $ 18.92万
  • 项目类别:
Conductance to Measure Cardiac Mechanics
用于测量心脏力学的电导
  • 批准号:
    6335940
  • 财政年份:
    2001
  • 资助金额:
    $ 18.92万
  • 项目类别:

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CORE D:磁共振成像核心 (MRIC)
  • 批准号:
    10201485
  • 财政年份:
    2018
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    $ 18.92万
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用漫射光评估肌肉血管疾病
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预防透析移植失败的超声波仪器
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    6887030
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    2005
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谐波多普勒超声栓塞表征
  • 批准号:
    7027750
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    2005
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Harmonic Doppler Ultrasound Embolus Characterization
谐波多普勒超声栓塞表征
  • 批准号:
    6882779
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    2005
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