Coordinating and Bioinformatics Unit for the AMDCC/MMPC

AMDCC/MMPC 协调和生物信息学单位

• 批准号: 7152230
• 负责人: Richard A. MCINDOE
• 金额: $ 294.5万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7152230
• 关键词: Internet; bioinformatics; biomedical resource; computer program /software; computer system design /evaluation; cooperative study; health science research support; meeting /conference /symposium; training

DESCRIPTION (provided by applicant): The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The AMDCC consists of 8 animal engineering centers, 3 phenotyping cores and 1 coordinating and bioinformatics unit (CBU) with investigators from 14 separate institutions. Oversight of the consortium comes from both the NIH and an External Advisory Committee (EAC). My laboratory is the current CBU for the AMDCC and is responsible for organizing the activities of the consortium, including the administrative responsibilities as well as the development of the informatics infrastructure required to store, disseminate and analyze the data generated by the AMDCC. In contrast, the MMPCs were charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Officially, these two consortia had no interaction or coordination of activities with regard to their respective missions. As part of the renewal of these two consortia, the NIH has decided to integrate and coordinate their activities. In order to facilitate this interaction, one CBU will be responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC CBU infrastructure to provide both the AMDCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each entity. Specifically, we will: 1) Provide Support for the Administrative and Coordinating Activities; and 2) Create and Maintain the Informatics Infrastructure Necessary to Support the Activities of both Consortia.

描述（由申请人提供）： 糖尿病并发症动物模型联盟 (AMDCC) 和小鼠代谢表型中心 (MMPC) 是由 NIH 资助的两个多中心项目。在当前的五年资助周期中，AMDCC 的主要职责是开发和表征模拟人类糖尿病并发症的动物模型。 AMDCC 由 8 个动物工程中心、3 个表型分析核心和 1 个协调和生物信息学单位 (CBU) 组成，研究人员来自 14 个不同的机构。该联盟的监督来自 NIH 和外部咨询委员会 (EAC)。我的实验室是 AMDCC 目前的 CBU，负责组织联盟的活动，包括管理职责以及开发存储、传播和分析 AMDCC 生成的数据所需的信息学基础设施。相比之下，MMPC 负责为科学界提供标准化、高质量的小鼠代谢和生理表型服务。 MMPC 向研究人员收费提供最先进的技术，其服务包括小鼠代谢特征、血液成分（包括激素）、能量平衡、饮食和运动、器官功能和形态、生理学和组织学。正式而言，这两个联盟在各自的任务方面没有任何互动或活动协调。作为这两个联盟更新的一部分，美国国立卫生研究院决定整合和协调他们的活动。为了促进这种互动，一个 CBU 将负责创建和维护组织和促进其运作所需的行政、科学和信息基础设施。该提案的目标是提供该基础设施。我们将在当前 AMDCC CBU 基础设施的成功基础上，为 AMDCC 和 MMPC 提供强大且全面的面向服务的解决方案，支持每个实体的共同和独特方面。具体来说，我们将： 1）为行政和协调活动提供支持； 2) 创建和维护支持两个联盟活动所需的信息学基础设施。