Disability from Pediatric Trauma Brain Injury

儿童脑外伤致残

• 批准号: 7183896
• 负责人: FREDERICK P. RIVARA
• 金额: $ 64.32万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7183896
• 关键词: adolescence (12-20); age difference; brain injury; child (0-11); child with disability; clinical research; disease /disorder proneness /risk; human subject; longitudinal human study; patient oriented research; pediatrics; trauma

Population based studies have estimated the incidence of TBI but have not provided population-based estimates of subsequent disability. This population-based information is important for the appropriate planning and delivery of services to children disabled by TBI. Objectives: (1) Determine the incidence of mild, moderate, and severe TBI in children and adolescents 0-18 years of age; (2) Determine the disability from different severities of TBI in children of different age groups; (3) Determine how this disability changes over time after injury; (4) Identify risk and protective factors for disability from TBI. Study Design: In this project, we will conduct a population-based surveillance of children and adolescents with TBI. From this surveillance, we will identify a sample of pediatric patients with TBI who will be recruited and enrolled in the study. This sample will be stratified by severity and age to allow adequate numbers of individuals at each severity level and each age group for study. Initial and base line measurements will be obtained, and patients will be followed over time to determine outcomes from TBI. Setting: Subjects will be identified in Emergency Departments, Hospitals and Medical Examiners in King County, Washington, and Philadelphia County, Pennsylvania. Participants: 1000 patients 0-18 years of age with mild, moderate or severe TBI. Outcome Measures: We will examine patient and family disability pre-injury and at 3, 12, 24, and 36 months post-TBl. This will include quality of life, social, emotional, behavioral and academic disability in patients and family functioning and parenting stress. Implications: This study will address many of these unanswered questions surrounding pediatric TBI. It will provide population-based rates of the incidence and disability fromTBI, including mild, moderate and severe based on medical record and interview data. It will follow patients and their families for three years after injury, examining the degree to which recovery plateaus in the months following TBI. It will examine factors which interact with the injury to produce disability, be they positive or negative influences on outcomes. The study team represents an interdisciplinary group of very experienced investigators to carry out a rigorous study to provide information to inform future research, care and policy.

基于人群的研究估计了 TBI 的发生率，但没有提供基于人群的后续残疾估计。这种基于人群的信息对于适当规划和向 TBI 致残儿童提供服务非常重要。 目的：(1) 确定 0-18 岁儿童和青少年轻度、中度和重度 TBI 的发生率 年龄； (2)确定不同年龄段儿童不同严重程度的TBI致残情况； (3) 确定这种残疾在受伤后如何随时间变化； (4) 识别风险和保护因素 TBI 造成的残疾。 研究设计：在这个项目中，我们将对儿童和青少年进行基于人群的监测 与创伤性脑损伤。从这次监测中，我们将确定将招募的 TBI 儿科患者样本 并参加了这项研究。该样本将按严重程度和年龄进行分层，以允许足够数量的 每个严重程度和每个年龄组的个体进行研究。初始和基线测量将是 获得，并且将随着时间的推移对患者进行随访以确定 TBI 的结果。 地点： 受试者将在 King 的急诊室、医院和法医处进行识别 华盛顿县和宾夕法尼亚州费城县。 参与者：1000 名 0-18 岁的轻度、中度或重度 TBI 患者。 结果衡量：我们将在受伤前以及受伤后 3、12、24 和 36 个月时检查患者和家人的残疾情况 结核病后。这将包括患者的生活质量、社交、情感、行为和学业障碍以及 家庭功能和养育压力。 意义：这项研究将解决许多有关儿科 TBI 的悬而未决的问题。它将 提供基于人群的 TBI 发病率和致残率，包括轻度、中度和重度 基于医疗记录和访谈数据。它将在三年后跟踪患者及其家人 损伤，检查 TBI 后几个月恢复稳定的程度。它将检查因素 它与伤害相互作用而产生残疾，无论它们对结果有积极还是消极的影响。这 研究团队由经验丰富的研究人员组成的跨学科小组组成，他们进行了严格的研究 研究提供信息，为未来的研究、护理和政策提供信息。