Development of Substance Use in Girls

女孩药物滥用的发展

• 批准号: 7037848
• 负责人: ROLF LOEBER
• 金额: $ 32.38万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037848
• 关键词: African American; alcoholism /alcohol abuse; behavior disorders; behavioral /social science research tag; caucasian American; child (0-11); disease /disorder proneness /risk; female; human subject; interpersonal relations; longitudinal human study; reproductive development; sex behavior; socioeconomics; substance abuse related behavior; substance abuse related disorder; tobacco abuse

DESCRIPTION (provided by applicant): The long-term development of female substance use, substance-related problems, and substance use disorders (SUDs) is poorly understood. In at least two ways, females appear more vulnerable to substance abuse and dependence compared to males: they demonstrate more rapid development from onset of use to SUD, and a higher propensity to develop comorbid psychopathology. In addition, early onset of substance use carries a higher risk of developing an SUD among females compared with males. The main goal of the proposed research is to investigate the early phases in the development towards frequent substance use, substance-related problems, and SUD. This proposal describes a substudy to the NIMH-funded Pittsburgh Girls Study (N = 2,451; 52 percent African-American, 41 percent Caucasian), an investigation of the development of antisocial behavior and delinquency in four age cohorts of girls, initially assessed at ages 5 to 8. The main study is now in its fifth yearly assessment (ages 9 to 12), and will continue for another 4 years. The proposed study requests a continuation of earlier funding by NIDA, which supported examination of the precursors and explanatory factors associated with girls' early substance use. The proposed research, through five yearly follow-up assessments of the child, the main caretaker, and teachers, extends this line of inquiry into the developmental period from age 10 to 17, when we expect that girls' substance use, substance- related problems, and comorbid conditions will increase. The aims of the proposed research are to: (1) describe developmental sequences of substance use by girls during the transition from childhood into adolescence within and across substances; (2) examine developmental sequences of substance use by girls in conjunction with the developmental course of comorbid conditions, especially psychopathology and other behavior problems; and (3) determine proximal and distal risk and protective factors (both generic and female-specific) for different developmental sequences of substance use by girls. These three aims, in conjunction with the data on early substance use and attitudes already collected, will link childhood factors to substance use during adolescence. The Pittsburgh Girl Study is one of the very few studies in the USA that can examine these relationships from childhood through adolescence.

描述（由申请人提供）：对女性物质使用，与物质相关的问题和物质使用障碍（SUD）的长期发育知之甚少。与男性相比，至少有两种方式，女性似乎更容易受到药物滥用和依赖的影响：从使用开始到SUD，它们表现出更快的发展，并且更倾向于发展合并症的心理病理学。此外，与男性相比，早期使用物质的发作具有更高的女性中SUD的风险。拟议的研究的主要目标是研究经常使用物质使用，与物质有关的问题和SUD的早期阶段。该提案描述了NIMH资助的匹兹堡女孩研究的一种物质（n = 2,451; 52％的非裔美国人，41％的高加索人），对四个年龄段的反社会行为和犯罪的发展进行了调查，最初是在5至8岁时评估的。拟议中的研究要求NIDA早期资助的延续，该研究支持对与女孩早期吸毒相关的前体和解释性因素的检查。拟议的研究通过对儿童，主要看护人和教师的每年五次随访评估，将这一调查范围从10岁到17岁扩展到17岁，当时我们期望女孩的物质使用，与物质相关的问题以及合并症的状况将会增加。拟议的研究的目的是：（1）描述女孩在从童年过渡到青春期内外物质内和跨物质中的物质使用的发育序列； （2）研究女孩与合并症的发展过程，尤其是心理病理学和其他行为问题的发展过程； （3）确定女孩的近端和远端风险以及保护因素（仿制药和女性特异性），以确定女孩使用物质使用的不同发育序列。这三个目的与已经收集的早期药物使用和态度的数据结合使用，将在青春期将童年因素与幼年的因素联系起来。匹兹堡女孩的研究是美国为数不多的研究，可以研究从童年到青春期的这些关系。