DEVELOPMENT OF SUBSTANCE USE IN GIRLS

女孩药物滥用的发展

• 批准号: 6628346
• 负责人: ROLF LOEBER
• 金额: $ 28.34万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6628346
• 关键词: African American; alcoholism /alcohol abuse; behavior disorders; behavioral /social science research tag; caucasian American; child (0-11); disease /disorder proneness /risk; female; human subject; interpersonal relations; longitudinal human study; reproductive development; sex behavior; socioeconomics; substance abuse related behavior; substance abuse related disorder; tobacco abuse

The long-term development of substance use and abuse in girls and women are poorly understood. In at least two ways, females compared to males appear more vulnerable to substance abuse and dependence: a speedier development from onset of use to abuse, and a higher propensity to develop comorbid conditions. In addition, females and males with an early onset of substance use are more likely to become substance abusers. The main goal of the proposed research is to investigate the early phases in this development process. Specifically, we propose to study precursors to the onset of early substance use (i.e., mainly alcohol and tobacco use), the transition to onset of use, and the transition to regular use in an inner-city community sample of 2,484 preadolescent girls. The girls, together with their parent and school teacher, will be assessed yearly and will be followed up over a period of five years. The sample will be made up of approximately 50 percent African-American and 50 percent Caucasian girls. The proposed study will be a substudy linked to and benefitting from the NIMH-funded study on the same girls, which has as its main object the study of the development of antisocial and delinquent behavior. The present proposal has three foci: 1). To identify the developmental precursors to the onset and regular use of substances; 2). To examine behavior problems which interact with early substance use; and 3) To elucidate the risk and protective factors predictive of the precursors of early substance use and predictive of the early use. The proposed study will be the foundation upon which follow-ups beyond the current five-year period can be built in order to better understand the long-term antecedents, risk and protective factors for substance abuse and dependence in females.

对女孩和妇女的毒品使用和滥用的长期发展知之甚少。 至少在两种方面，与雄性相比，女性似乎更容易受到药物滥用和依赖的影响：从使用开始到滥用开始，较快的发展，以及更高的发展疾病的倾向。 另外，早期使用物质使用的女性和男性更有可能成为滥用药物。 拟议的研究的主要目标是研究此开发过程中的早期阶段。 具体而言，我们建议研究早期使用物质使用的前体（即主要是酒精和烟草使用），过渡到使用的过渡以及在2,484个preadoledepent Girls的城市内部社区样本中定期使用的过渡。 这些女孩以及她们的父母和学校老师将每年进行评估，并将在五年内进行跟进。 该样本将由约50％的非裔美国人和50％的高加索女孩组成。 拟议的研究将是一项与NIMH资助的对同一女孩的研究相关并受益的方法，该研究具有其主要对象，是反社会和犯罪行为发展的研究。 本提案有三个焦点：1）。 识别出发作和定期使用物质的发育前体； 2）。 检查与早期药物使用相互作用的行为问题； 3）阐明了预测早期使用物质的前体的风险和保护因素，并预测了早期使用的预测。 拟议的研究将是可以建立超出当前五年的后续行动的基础，以便更好地了解女性滥用药物和依赖性的长期前因，风险和保护因素。