Conference: Biology of Calpains in Health and Disease

会议：钙蛋白酶在健康和疾病中的生物学

• 批准号: 6762941
• 负责人: NEIL E FORSBERG
• 金额: $ 1.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-03 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6762941
• 关键词: apoptosis; biological signal transduction; calpain; meeting /conference /symposium; pathologic process; protease inhibitor; protein structure function; travel

DESCRIPTION (provided by applicant): A FASEB Summer Conference titled "Biology of Calpains in Health and Disease" is scheduled for June 12-17, 2004. The meeting will be held in Tuscon, Arizona. This will be the third FASEB-sponsored Calpain meeting. Funds are being requested from three NIH divisions (NIAMS, NIDDK and NEI) in partial support of this conference. The thematic sessions for the conference will be: 1) Calpain Gene Family, 2) Calpain Structure, 3) Physiological Roles, 4) Calpains and Signal Transduction, 5) Pathologic Involvement of Calpains, 6), Calpain Inhibitors in Treatment of Disease, 7) Agricultural Applications and 8) A Holistic View (two sessions). The latter session (A Holistic View) is designed to stimulate thoughts on how the calpains participate, in tandem with other proteases, in mediation of normal and pathological processes (e.g., apoptosis and myofibrillar protein degradation). This topic will be supported by a keynote speaker who is a leader in the biology of cysteine proteases (Dr. Alan Barrett, Babraham Institute) and by speakers who have expertise with other proteolytic systems (notably the ubiquitin/proteasome system). A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathologic processes. The activities of the house-keeping u- and m-calpains are important to normal turnover and processing of cytoskeletal and membrane proteins in all tissues. A defective muscle-specific calpain (p94) is responsible, in part, for Limb-Girdle Muscular Dystrophy Type IIA. Interestingly, the gene encoding p94 is also expressed as a lens-specific calpain isoform (Lp82) which, when activates, underlies cataractogenesis. Defects in calpain-10 have now been related to adult onset diabetes and to cystic ovary disease. Skeletal and cardiac muscle damage as well as cerebral ischemia have been related to pathologic activation of calpains. Three years will have passed since the last meeting on calpains. Substantial progress on the genomics, biology, structure, activation and roles of calpains has been made in the past few years. The proposed program will provide the forum by which the momentum in this field may be maintained.

描述（由申请人提供）： 题为“健康与疾病中钙蛋白酶生物学”的 FASEB 夏季会议定于 2004 年 6 月 12 日至 17 日举行。会议将在亚利桑那州图斯康举行。这将是 FASEB 主办的第三次 Calpain 会议。 NIH 的三个部门（NIAMS、NIDDK 和 NEI）正在申请资金来部分支持本次会议。 会议的主题会议包括：1) 钙蛋白酶基因家族，2) ​​钙蛋白酶结构，3) 生理作用，4) 钙蛋白酶和信号转导，5) 钙蛋白酶的病理学参与，6) 钙蛋白酶抑制剂在疾病治疗中的作用，7 ) 农业应用和 8) 整体观点（两场会议）。后一环节（整体观点）旨在激发人们对钙蛋白酶如何与其他蛋白酶协同参与介导正常和病理过程（例如细胞凋亡和肌原纤维蛋白降解）的思考。本主题将由半胱氨酸蛋白酶生物学领域的领导者（Alan Barrett 博士，巴布拉汉姆研究所）的主讲人以及具有其他蛋白水解系统（特别是泛素/蛋白酶体系统）专业知识的演讲者提供支持。 关于钙蛋白酶生物学的会议与 NIH 高度相关，因为钙蛋白酶参与正常和病理过程。管家 u 和 m 钙蛋白酶的活性对于所有组织中细胞骨架和膜蛋白的正常周转和加工都很重要。肌肉特异性钙蛋白酶 (p94) 缺陷是 IIA 型肢带型肌营养不良症的部分原因。有趣的是，编码 p94 的基因也表达为晶状体特异性钙蛋白酶亚型 (Lp82)，当其激活时，它是白内障发生的基础。 calpain-10 缺陷现已与成人糖尿病和囊性卵巢病相关。骨骼和心肌损伤以及脑缺血与钙蛋白酶的病理激活有关。 距离上次关于钙蛋白酶的会议已经过去三年了。过去几年，钙蛋白酶的基因组学、生物学、结构、激活和作用方面取得了实质性进展。拟议的计划将提供一个论坛，通过该论坛可以维持该领域的势头。