FASEB Conference-Protein Lipidation and Membrane Domains

FASEB 会议-蛋白质脂化和膜结构域

• 批准号: 6808660
• 负责人: ANANT K MENON
• 金额: $ 0.65万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808660
• 关键词: acylation; biological signal transduction; biological transport; carcinogenesis; enzyme induction /repression; enzyme inhibitors; glycosylphosphatidylinositols; lipid structure; meeting /conference /symposium; membrane activity; membrane structure; pathologic process; posttranslational modifications; protein structure function; proteolipids; travel

DESCRIPTION (provided by applicant): We request partial support for a Federation of American Biological Societies of Experimental Biology (FASEB) conference entitled 'Protein Lipidation, Signaling and Membrane Domains,' to be held July 24-29, 2004 at Tucson, AZ. This meeting will highlight exciting recent progress, and provide a needed forum for critical discussions, concerning lipid-modified proteins and membrane microdomains and their roles in processes including signal transduction, trafficking of membrane molecules and disease pathogenesis. The meeting will be organized around three main themes. First, it will provide a very timely opportunity for the exchange and critical evaluation of information about the nature of membrane microdomains in living cells and their roles in functions such as cell signaling and membrane trafficking. Recent work in these areas has generated much excitement but has also clearly indicated a need for more rigorous, multifaceted strategies to address these issues. Second, the conference will highlight recent evidence that lipid-modified proteins and membrane domains play important roles in the pathogenesis of cancer, infectious diseases and inherited disorders, and it will present current progress in the development of inhibiters of protein lipidation as potential therapeutic agents for the treatment of cancer (protein prenyltransferase inhibitors) and parasitic infections (inhibitors of enzymes involved in protein myristoylation and glycosylphosphatidylinositol [GPI-] anchorage). Finally, the meeting will feature new developments in understanding the enzymology of protein lipidation, including recent successes in characterizing the enzymes involved in coupling S-acyl and GPIanchor' groups to proteins, using combined genetic and biochemical approaches. With its unique dual focus on the complementary areas of lipid-modified proteins and membrane microdomains, this meeting will promote important sharing of information by researchers from fields ranging from biophysics and structural biology to immunology and cancer biology.

描述（由申请人提供）：我们请求对将于 2004 年 7 月 24 日至 29 日在亚利桑那州图森举行的美国实验生物学学会联合会 (FASEB) 题为“蛋白质脂化、信号传导和膜域”的会议提供部分支持。本次会议将重点介绍令人兴奋的最新进展，并为关键讨论提供必要的论坛，涉及脂质修饰蛋白和膜微结构域及其在信号转导、膜分子运输和疾病发病机制等过程中的作用。 会议将围绕三个主题进行。首先，它将提供一个非常及时的机会，用于交换和批判性评估有关活细胞中膜微结构域的性质及其在细胞信号传导和膜运输等功能中的作用的信息。这些领域最近的工作令人兴奋，但也明确表明需要采取更严格、多方面的策略来解决这些问题。其次，会议将重点介绍脂质修饰蛋白和膜结构域在癌症、传染病和遗传性疾病的发病机制中发挥重要作用的最新证据，并将介绍蛋白质脂化抑制剂作为潜在治疗药物的最新进展。治疗癌症（蛋白质异戊烯基转移酶抑制剂）和寄生虫感染（参与蛋白质肉豆蔻酰化和糖基磷脂酰肌醇 [GPI-] 锚定的酶抑制剂）。最后，会议将重点介绍蛋白质脂化酶学方面的新进展，包括最近使用遗传和生化相结合的方法对参与 S-酰基和 GPIanchor 基团与蛋白质偶联的酶进行表征的成功。 由于其独特的双重关注脂质修饰蛋白和膜微结构域的互补领域，本次会议将促进生物物理学、结构生物学、免疫学和癌症生物学等领域的研究人员重要的信息共享。