Novel Brain Neuroimaging Markers of Age-Related Mobility Impairment

与年龄相关的活动障碍的新型脑神经影像标记

• 批准号: 7152096
• 负责人: Caterina Rosano
• 金额: $ 21.55万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7152096
• 关键词: aging; balance; bioimaging /biomedical imaging; biomarker; brain imaging /visualization /scanning; clinical research; disease /disorder proneness /risk; gait; geriatrics; gray matter; human data; human old age (65+); human subject; hypertension; inflammation; longitudinal human study; magnetic resonance imaging; neural degeneration; neural information processing; neuropathology; patient oriented research; person with disability; physical fitness; restricted physical activity; white matter

DESCRIPTION (provided by applicant): Gait slowing and balance problems often develop in older adults in the absence of a specific disease or acute clinical event, but rather as a consequence of age-related changes in the nervous, musculoskeletal or cardiorespiratory system. A multidisciplinary study of such unexplained age-related mobility impairment looks both at its peripheral and central contributors and it therefore requires a strong foundation in geriatric assessment, neuroimaging and neuroepidemiology. Dr. Rosano is a physician neuroepidemiologist who aims to prevent age-related mobility impairment by targeting structural and functional brain integrity. As a new Pepper scholar and junior faculty, her line of research provides evidence for an independent association between subclinical white matter (WM) abnormalities and focal gray matter (GM) atrophy with mobility. She now seeks external funding for a 3 year career award application to address the following three aims: 1) to identify the earliest structural WM and GM changes associated with unexplained age-related mobility impairment, 2) to examine the spatial and temporal relationship of WM and GM subclinical abnormalities in mobility-related areas and 3) to identify the possible causes and risk factors of such brain abnormalities. The application consists of two complementary projects. In Project 1, she will utilize existing paired brain MRIs collected 5 year apart in 2,109 participants of the Cardiovascular Health Study (CHS) to measure the association between changes in focal WM hyperintensities and GM atrophy with mobility. In Project 2, she will use advanced neuroimaging techniques to acquire 250 brain MRIs from the Health, Aging and Body Composition study participants (Health ABC) and she will measure WM, GM and cortical connections' abnormalities that are undetectable with conventional MRI. Dr. Rosano will exploit the CHS and Health ABC unique longitudinal cohorts data on mobility, health related factors, cardiovascular and inflammatory markers that span a follow-up time of over 10 years. Dr. Anne Newman, an internationally recognized leader in multidisciplinary aging research, and a team of experts in cerebrovascular epidemiology, mobility research, and geriatric neuroimaging will assist Dr. Rosano's work. This award will consolidate Dr. Rosano's knowledge of longitudinal data analysis, will advance her expertise of cutting-edge neuroimaging techniques, and will strengthen her ability to independently execute large longitudinal epidemiological studies.

描述（由申请人提供）：在没有特定疾病或急性临床事件的情况下，老年人的步态减慢和平衡问题通常会出现，而是由于年龄相关的神经，肌肉骨骼或心脏呼吸系统的变化而导致的。对这种无法解释的与年龄相关的流动性障碍的多学科研究既涉及其外围和中央贡献者，因此需要在老年人评估，神经影像学和神经性ePidemiology方面具有良好的基础。 Rosano博士是一名医生神经性电子检查员，旨在通过靶向结构和功能性脑完整性来防止与年龄相关的活动性障碍。作为一名新的胡椒学者和初级教师，她的研究领域为亚临床白质（WM）异常与局灶性灰质（GM）萎缩与流动性之间的独立关联提供了证据。她现在寻求外部资金以解决三年的职业奖项申请，以解决以下三个目的：1）确定与无法解释的与年龄相关的流动性障碍相关的最早的结构性WM和GM的变化，2）检查WM和GM亚临床异常的空间和时间关系，以确定与您相关区域中的行动不便和3）可能的因素和3）可能的因素和3）。该申请由两个补充项目组成。在项目1中，她将利用现有的配对脑MRIS在2,109名心血管健康研究（CHS）的参与者中收集了5年，以衡量局灶性WM超强度的变化与GM萎缩与流动性之间的关联。在项目2中，她将使用先进的神经影像学技术从健康，衰老和身体组成研究参与者（Health ABC）中获取250个脑部MRI，并将测量WM，GM和皮质连接的异常，而常规MRI则无法检测到。 Rosano博士将利用有关移动性，与健康相关因素，心血管和炎症标记的CHS和健康ABC独特的纵向人群数据，这些数据涵盖了10多年的随访时间。跨学科衰老研究的国际认可领导者安妮·纽曼（Anne Newman）博士以及脑血管流行病学，流动性研究和老年神经影像学专家团队将有助于Rosano博士的工作。该奖项将巩固Rosano博士对纵向数据分析的了解，将提高她在尖端神经影像技术方面的专业知识，并将增强她独立执行大型纵向流行病学研究的能力。