Clinical Hematology Research Career Development Program at Washington University

华盛顿大学临床血液学研究职业发展计划

• 批准号: 7192596
• 负责人: J Evan Sadler
• 金额: $ 36.14万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-28 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7192596
• 关键词: bone marrow disorder; career; clinical research; curriculum; epidemiology; health science research potential; hematology; hemoglobinopathy; mentoring /mentor; statistics /biometry; thrombosis; training

DESCRIPTION (provided by applicant): The objectives of the Clinical Hematology Research Career Development Program at Washington University are to develop and evaluate a multidisciplinary career development program that will prepare trainees (Scholars) to address complex problems in non-malignant blood diseases. Scholars will be clinical or research fellows, clinical or research instructors, or recently appointed assistant professors. Scholars are expected to become independent researchers and assume leadership roles in non-malignant clinical hematology. During the first year, Scholars will pursue a Clinical Core Curriculum that involves inpatient and outpatient care of patients with specific non-malignant hematologic disorders, and a Didactic Clinical Research Curriculum that teaches the skills necessary for independent and ethical clinical research. This first-year curriculum will draw on the strengths of existing K30 and degree granting programs in biostatistics, epidemiology, and clinical research at Washington University. Toward the end of the first year, each Scholar will begin a one or two year intensive Mentored Research Experience to generate publishable results and preliminary data for subsequent independent grant applications. The program will focus on three major areas of non-malignant hematologic disease: (1) bone marrow failure syndromes, including paroxysmal nocturnal hemoglobinuria, aplastic anemia, congenital anemias, and myleodysplastic syndrome; (2) hemostatic and thrombotic disorders, including von Willebrand disease, thrombotic microangiopathy, and other congenital or acquired hemorrhagic or thrombotic syndromes; and (3) sickle cell disease and other hemoglobinopathies. These research projects will encompass pediatric, adolescent and adult subjects with non-malignant hematologic disorders. Implicit in these objectives is our commitment to recruit outstanding Scholars from diverse backgrounds, to individualize their training based on their needs and experience, to continuously monitor and improve the curriculum, and to track Scholar performance. By these means, the proposed career development program will increase our national capacity for translational, multidisciplinary research in non-malignant clinical hematology and alleviate the shortage of academic physician-scientists in this medically important discipline.

描述（由申请人提供）： 华盛顿大学临床血液学研究职业发展计划的目标是制定和评估一项多学科职业发展计划，该计划将准备受训者（学者），以解决非恶性血液疾病的复杂问题。学者将是临床或研究研究员，临床或研究讲师，或最近任命的助理教授。预计学者将成为独立的研究人员，并在非恶性临床血液学中扮演领导角色。在第一年，学者将探讨一项临床核心课程，该课程涉及患有特定非恶性血液学疾病的患者的住院和门诊护理，以及教授独立和道德临床研究所需的技能的教学疗法临床研究课程。该第一年课程将借鉴华盛顿大学的生物统计学，流行病学和临床研究的现有K30和学位授予计划的优势。在第一年底，每个学者将开始一两年的密集指导研究经验，以为后续独立赠款申请产生可发布的结果和初步数据。该计划将重点关注非恶性血液学疾病的三个主要领域：（1）骨髓衰竭综合征，包括阵发性夜间血红蛋白尿症，性障碍性贫血，先天性贫血和肌毛dyplassplastal综合征； （2）包括von Willebrand疾病，血栓形成微型血管病以及其他先天性或获得的出血或血栓形成综合症在内的止血和血栓性疾病； （3）镰状细胞疾病和其他血红蛋白病。这些研究项目将涵盖患有非恶性血液学疾病的小儿，青少年和成年受试者。这些目标的隐含是我们致力于从不同背景招募出色的学者，根据他们的需求和经验来个性化培训，不断监视和改善课程，并跟踪学者表现。通过这些手段，拟议的职业发展计划将提高我们在非政体临床血液学中进行转化，多学科研究的能力，并减轻学术医师科学家在这项医学上重要的学科中的短缺。