A Method for the Alkylation of Alcohols and Amines

醇和胺的烷基化方法

• 批准号: 7157188
• 负责人: Seth B. Herzon
• 金额: $ 4.4万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-14 至 2009-08-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157188
• 关键词: alcohols; aldehydes; alkaloids; alkenes; alkylation; amines; biological products; chemical conjugate; chemical synthesis; combinatorial chemistry; imines; indoles; method development; plants; postdoctoral investigator; stereochemistry; stereoisomer

DESCRIPTION (provided by applicant): This goal of this research is the development of a new method for the stereocontrolled synthesis of secondary alcohols, acylic aliphatic amines, 1,2-diols, 1,2-amino alcohols, and 1,2-diamines. Such motifs are found in compounds of biological and medicinal importance, the drugs Taxol, vancomycin, and indinivar being notable examples. The method will allow for the formation of these compounds directly from primary alcohols and acylic aliphatic amines, starting materials which are abundant and widely accesible. It is envisioned that the technologies developed in this program will find use in the synthesis of natural and unnatural therapeutic agents; this will be demonstrated by the application of these methods to the total synthesis of the Strychnos alkaloid (-)-dehydrotubifoline. A portion of the research will examine the development of asymmetric C-H bond activation processes, an area of chemistry which is still largely unexplored.

描述（由申请人提供）：这项研究的目标是开发一种新方法，用于立体控制的二次醇，辅助脂肪胺，1,2-二醇，1,2-氨基醇和1,2-二胺。这种基序是在生物学和药物重要性的化合物中发现的，药物紫杉醇，万古霉素和indinivar是著名的例子。该方法将允许直接从原发性醇和辅助脂族胺中形成这些化合物，这些胺的起始材料丰富且可广泛。可以预见，该计划中开发的技术将在合成自然和不自然的治疗剂中使用。这些方法将这些方法应用于Strychnos生物碱（ - ） - 脱氢dubibifoline的总合成中。一部分研究将研究不对称的C-H键激活过程的发展，这是化学领域，但仍未探索。