Recruitment and Assessment Core Patient Recruitment

招募和评估核心患者招募

• 批准号: 7167309
• 负责人: DAVID C. STEFFENS
• 金额: $ 39.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7167309
• 关键词: behavioral /social science research tag; biomedical facility; cardiovascular disorder; cognition; depression; human old age (65+); magnetic resonance imaging; mass screening; medical outreach /case finding; neuropsychological tests

The objective of this Recruitment and Assessment (R&A) Core for the CCNMD is to support all of the Center's projects. There are seven main aims of R&A: 1) To implement a well functioning screening, recruitment and assessment process for CCNMD projects; 2) To recruit elderly and young (> 60 yrs) patients meeting entry criteria per year for CCNMD projects; 3) To recruit and screen the normal, age-matched and young volunteers required for CCNMD projects; 4) To maintain a quality control system to monitor the work of the assessment core staff for reliability; 5) To conduct standardized MRI studies for patient assessment and to collect blood for genetic analyses; 6) Allocation of patients to different projects and ensuring that there is no undue burden on subjects; and 7) To develop and maintain an autopsy resource. The R&A Core will meet these goals chiefly through highly trained key personnel and research staff, including research psychiatrists, neuropsychologist, research assistants, a neuropsychological technician, a neuropathologist, and an Autopsy Coordinator. Subjects will receive a thorough psychiatric assessment, medical assessment, a detailed review of cardiovascular and cerebrovascular risk factors, standardized neurological examination, and a standardized cognitive assessment including a comprehensive neuropsychological test battery. Patients will be recruited through a variety of sources, including the impatient service at Duke and a state hospital, Duke affiliated clinics, the Duke ECT services, clinical trials, and an NIMH-sponsored naturalistic longitudinal study of depression. Elderly controls will be obtained through an Aging Center Registry of elderly volunteers. Young controls will be recruited through a similar data base. The R&A staff will work to ensure that all subjects have completed CCNMD protocols. R&A staff will find appropriate follow-up for depressed subjects, either through referral or enrollment in other research studies.

CCNMD的招聘和评估（R＆A）核心的目的是支持所有 中心的项目。 R＆A的主要目标有七个：1）实施功能良好的筛选， CCNMD项目的招聘和评估过程； 2）招募老年人和年轻人（> 60岁） 患者每年符合CCNMD项目的入境标准； 3）招募和筛选正常 CCNMD项目所需的年龄匹配和年轻志愿者； 4）保持质量控制 监视评估核心人员的工作的系统； 5）进行标准化的MRI 研究患者评估并收集血液以进行遗传分析； 6）将患者分配给 不同的项目，并确保对象没有不适当的负担； 7）开发和 保持尸检资源。 R＆A核心将主要通过训练有素的关键人员和研究人员来满足这些目标， 包括研究精神科医生，神经心理学家，研究助理，神经心理学 技术人员，神经病理学家和尸检协调员。受试者将获得彻底的 精神病评估，医学评估，心血管和 脑血管风险因素，标准化神经检查和标准化认知 评估包括全面的神经心理测试电池。 将通过多种来源招募患者，包括杜克的不耐烦和 州医院，杜克大学附属诊所，杜克ECT服务，临床试验和NIMH赞助 抑郁症的自然主义纵向研究。老年对照将通过衰老获得 老年志愿者中心注册表。年轻控件将通过类似的数据库招募。 R＆A工作人员将努力确保所有受试者都完成了CCNMD协议。 R＆A工作人员会 通过推荐或其他人数找到抑郁症受试者的适当随访 研究。