PATHOLOGY OF THE LABORATORY MOUSE

实验室小鼠的病理学

• 批准号: 7091397
• 负责人: JOHN Paul SUNDBERG
• 金额: $ 2.64万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-25 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091397
• 关键词: biological models; disease /disorder model; genetic models; health science research; histopathology; laboratory mouse; meeting /conference /symposium; travel; workshop

DESCRIPTION (provided by applicant): Scientists are currently in the midst of a genetics revolution that promises to push "breakthrough" biomedical research to new levels. A large part of this revolution depends upon the analysis of the relationships between genes and their effects on complex biological systems and phenotypes. Investigators must become increasingly skilled in the manipulation and use of genetic models to address a variety of important biological questions. The laboratory mouse has become the premier animal model for human and domestic animal diseases as well as the model of choice for studying basic biological functions. Establishing the validity of such models depends on interaction between molecular biologists, geneticists, and pathologists, all of which have overlapping, but distinct skills. This is especially true for the pathologists since most are trained as physicians who have little to no appreciation of interspecies variability and/or similarity. Likewise, veterinary pathologists, although used to working with many species, have little or no human pathology experience and often little or no mouse pathology expertise. The escalation in the production and use of genetically engineered mice has created a demand for individuals with mouse pathology expertise. Due to this severe deficit in pathologists with such expertise, the literature is being flooded with incomplete and inaccurate descriptions of phenotypic effects of mutated genes. In order to help address this problem, the investigators propose a workshop, "Pathology of the Laboratory Mouse," to be held in the Fall each year initially, for five years. The Jackson Laboratory will host the workshop in the odd-numbered years (one, three, and five) whereas Cornell and Purdue will alternately host the workshop in the even numbered years. Coupled with modest fees, these offsite options are intended to make the workshop more accessible to students. The workshop itself will consist of eight days of intensive bench training sessions in pathology and histopathology, as well as didactic sessions in which particular disease areas and models will be discussed. The Workshop will accommodate 16 participants who will have an opportunity to interact with a group of prominent mouse pathologists and geneticists from both TJL, and other leading institutions.

描述（由申请人提供）：科学家目前正处于遗传学革命的中间，该革命有望将“突破”生物医学研究推向新水平。 这次革命的很大一部分取决于对基因之间的关系及其对复杂生物系统和表型的影响的分析。 研究人员必须在操纵和使用遗传模型方面越来越熟练，以解决各种重要的生物学问题。 实验室小鼠已成为人类和家庭动物疾病的主要动物模型，以及研究基本生物学功能的首选模型。 建立此类模型的有效性取决于分子生物学家，遗传学家和病理学家之间的相互作用，所有这些模型都具有重叠但不同的技能。对于病理学家而言，尤其如此，因为大多数人都是对种间变异性和/或相似性几乎没有欣赏的医生的训练。 同样，兽医病理学家虽然习惯与许多物种一起工作，但几乎没有人类病理学经验，通常很少或没有小鼠病理学专业知识。 基因工程小鼠的生产和使用的升级为具有小鼠病理学专业知识的人的需求。 由于具有这种专业知识的病理学家的严重缺陷，文献被突变基因表型作用的不完整和不准确描述所淹没。 为了帮助解决这个问题，调查人员提出了一个研讨会，即“实验室老鼠的病理学”，最初将在每年秋季举行五年。 杰克逊实验室将在奇数年份（一，三和五）中举办研讨会，而康奈尔和普渡大学将在偶数年的时间内交替举办研讨会。 加上适中的费用，这些异地选项旨在使学生更容易访问研讨会。 研讨会本身将包括八天的病理学和组织病理学的强化基础培训课程，以及将讨论特定疾病领域和模型的教学会议。 该研讨会将容纳16名参与者，他们将有机会与TJL和其他领先机构的一组著名的小鼠病理学家和遗传学家进行互动。