Parkinson's Disease Neuroprotection Clinical Trial

帕金森病神经保护临床试验

• 批准号: 7020665
• 负责人: JOANNE M WOJCIESZEK
• 金额: $ 0.61万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7020665
• 关键词: Parkinson' s disease; chemoprevention; clinical research; clinical trials; cooperative study; human subject; human therapy evaluation; medical outreach /case finding; nervous system disorder therapy; neuropharmacology; neuroprotectants; patient oriented research

DESCRIPTION (provided by applicant): The objective of this multiple center clinical trial will be to determine safety, tolerability and efficacy of one or more agents as neuroprotective therapies for Parkinson's disease (PD). The Movement Disorders Clinic at Indiana University will make a commitment to enroll 84 subjects in three and a half years for the pilot studies (n=12) and for the main clinical trial (n=72). The duration of the study will be 6-8 years. The investigators and the nurse coordinator possess clinical expertise in treating PD and have substantial experience in executing clinical protocols for PD. Recruitment of subjects will be from PD clinics at a tertiary care center and at a country hospital to maximize the potential for encouraging minorities and women to participate in these studies. The agents under study and the final design of the trials have yet to be determined.

描述（由申请人提供）：该多个中心临床试验的目的是确定一种或多种药物作为帕金森氏病（PD）的神经保护疗法的安全性，耐受性和功效。印第安纳大学的运动障碍诊所将承诺在三年半内招募84名受试者进行试点研究（n = 12）和主要的临床试验（n = 72）。该研究的持续时间将为6 - 8年。研究人员和护士协调员在治疗PD方面具有临床专业知识，并且在执行PD的临床方案方面具有丰富的经验。受试者的招募将来自三级护理中心的PD诊所和乡村医院，以最大程度地鼓励少数民族和妇女参加这些研究。正在研究的代理和试验的最终设计尚未确定。