Linear Ion-Trap /Fourier Transform Mass Spectrometer

线性离子阱/傅里叶变换质谱仪

基本信息

批准号：
6877215
负责人：
CHAD C NELSON
金额：
$ 50万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2006-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal is a request for funds to purchase a linear ion-trap/fourier transform mass spectrometer (Thermo Finnigan LTQ-FT) to upgrade the Mass Spectrometry and Proteomics Core Facility at the University of Utah. Characterization of complex proteins and modifications is central to the specific aims of more than 80 NIH-funded researchers at the University of Utah. Currently, the institution does not have instrumentation capable of meeting the existing and growing needs of these investigators. The LTQ-FT instrument is state-of-the-art and will provide ultra-high sensitivity, high mass accuracy, high resolution, and fast scanning capabilities, enabling researchers to achieve their challenging proteomics goals. It will also have many applications in other areas of biomedical research, such as structure elucidation of natural products. Many major users have been identified with existing and future projects that will ensure immediate and continued full-capacity usage. Also, the instrument will be made available to investigators from other regional institutions. The LTQ-FT will be housed in a central mass spectrometry core facility that has been in operation for more than 25 years. It will continue to be administered by the institution within a core-facilities framework which includes monitoring by an oversight committee and an advisory committee. There is very strong institutional support for this instrument. The institution is committed to providing a state-of-the-art proteomics resource which will build a close-working, collaborative role with investigators. The institution will guarantee funding for the balance of the cost of the instrument, continued financial support, maintenance, full-time operation from expert mass spectrometrists, and appropriate space within the Proteomics Core Facility. As part of this commitment, the institution recently hired a full-time director and will hire additional Ph.D. staff to operate the instrument for users.

描述（由申请人提供）：本提案请求资金购买线性离子阱/傅立叶变换质谱仪 (Thermo Finnigan LTQ-FT)，以升级犹他大学的质谱和蛋白质组学核心设施。复杂蛋白质和修饰的表征对于犹他大学 80 多名 NIH 资助的研究人员的具体目标至关重要。目前，该机构没有能够满足这些研究人员现有和不断增长的需求的仪器。 LTQ-FT 仪器是最先进的，将提供超高灵敏度、高质量精度、高分辨率和快速扫描功能，使研究人员能够实现具有挑战性的蛋白质组学目标。它还将在生物医学研究的其他领域有许多应用，例如天然产物的结构阐明。许多主要用户已确定现有和未来的项目，这将确保立即和持续的满负荷使用。此外，该工具还将提供给其他区域机构的研究人员。 LTQ-FT 将安装在已运行超过 25 年的中央质谱核心设施中。它将继续由该机构在核心设施框架内进行管理，其中包括监督委员会和咨询委员会的监督。该文书得到了非常强有力的机构支持。该机构致力于提供最先进的蛋白质组学资源，与研究人员建立密切的合作关系。该机构将保证仪器成本平衡的资金、持续的财务支持、维护、质谱专家的全职操作以及蛋白质组学核心设施内的适当空间。作为这一承诺的一部分，该机构最近聘请了一名全职董事，并将聘请更多的博士。工作人员为用户操作仪器。