Exceptional aging: 12 year trajectories to function

非凡的老化：12 年的功能轨迹

• 批准号: 7096663
• 负责人: ANNE B. NEWMAN
• 金额: $ 105.94万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7096663
• 关键词: aging; androgens; behavioral /social science research tag; blood chemistry; body physical activity; body physical characteristic; cardiovascular disorder; clinical research; cognition disorders; computed axial tomography; cytoskeletal proteins; functional ability; health behavior; human old age (65+); human subject; human very old age (85+); insulinlike growth factor; interleukin 6; interview; longitudinal human study; muscle strength; outcomes research; prognosis; questionnaires; tumor necrosis factor alpha

DESCRIPTION (provided by investigator): Functional aging, or disability-free survival, becomes increasingly exceptional as older adults reach age 80 and beyond. In the long- term survivors of the Cardiovascular Health Study (CHS) cohort, we will determine the likelihood of maintaining function, identify the trajectories that distinguish those destined to do well, and define the importance, independence and interactions of physiologic predictors of function. The CHS cohort is now aged 80 to 100+ with over 12 years of follow-up, but have not been examined for 4 years. With the long term, longitudinal data and a reassessment of functional status, we can identify critical targets and time points that could lead to potential intervention to extend functional years of life. We have shown that subclinical cardiovascular disease alone, in the absence of any clinically recognized CVD event, predicts impaired physical and cognitive function. However, CVD does not fully explain the very strong effect of age itself on decline in function. We can also determine the potential for maintaining function in the presence of CVD. We have noted that many participants over age 80 have maintained physical and cognitive function in spite of extensive subclinical CVD. The aims of this application are: 1) to identify and characterize CHS participants who have remained functional after age 80, specifically to determine the trajectories of CVD risk factors and behavioral factors, especially physical activity and CVD treatment that lead to functional aging, 2) to determine whether low levels of IL-6 and TNF-alpha, as well as CRP, high levels of adrenal androgens, and insulin-like growth factor-1 and adiponectin, and lower fasting insulin and glucose will predict continued functioning independently of cardiovascular disease, 3) to identify individuals who have maintained functional aging in the presence of a large atherosclerotic burden and to examine factors that may promote function in spite of CVD, 4) to determine whether the predictors of a functional aging predict continuous parameters of function including leg muscle strength, grip strength, gait speed, and cognitive processing speed. With longitudinal data collected over many years, the CHS is now uniquely positioned to answer these questions about aging. This study is a critical step towards the identification of the targets and the time points for intervention to preserve function in old age.

描述（由研究者提供）：随着老年人达到80岁及以上的年龄，功能性衰老或无残疾生存率变得越来越出色。在心血管健康研究（CHS）队列的长期幸存者中，我们将确定保持功能的可能性，确定区分原定做得好的轨迹，并确定功能的生理预测因子的重要性，独立性和相互作用。 CHS队列现年80至100岁以上，随访超过12年，但已有4年没有检查。长期，纵向数据和功能状态的重新评估，我们可以确定可能导致潜在干预以延长功能寿命的关键目标和时间点。我们已经表明，在没有任何临床认可的CVD事件的情况下，仅亚临床心血管疾病预测了身体和认知功能受损。但是，CVD并不能完全解释年龄本身对功能下降的非常强烈的影响。我们还可以确定在CVD存在下保持功能的潜力。我们注意到，尽管有广泛的亚临床CVD，许多80岁以上的参与者仍保持身体和认知功能。 The aims of this application are: 1) to identify and characterize CHS participants who have remained functional after age 80, specifically to determine the trajectories of CVD risk factors and behavioral factors, especially physical activity and CVD treatment that lead to functional aging, 2) to determine whether low levels of IL-6 and TNF-alpha, as well as CRP, high levels of adrenal androgens, and insulin-like growth factor-1 and adiponectin, and lower fasting insulin and glucose will predict continued functioning independently of cardiovascular disease, 3) to identify individuals who have maintained functional aging in the presence of a large atherosclerotic burden and to examine factors that may promote function in spite of CVD, 4) to determine whether the predictors of a functional aging predict continuous parameters of function including leg muscle strength, grip strength, gait speed, and cognitive processing speed.随着纵向数据收集了很多年，CHS现在可以独特地回答有关衰老的问题。这项研究是迈向确定目标的关键一步，以及在老年保留功能的干预时间点。