Novel Solid State Diabetes Monitoring System

新型固态糖尿病监测系统

• 批准号: 6761888
• 负责人: HANS G KLOEPFER
• 金额: $ 36.01万
• 依托单位: MICRONIX, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6761888
• 关键词: beta hydroxybutyrate; bioengineering /biomedical engineering; biomedical equipment; biomedical equipment development; blood chemistry; blood glucose; cholesterol; clinical research; diabetes mellitus; diabetic angiopathy; glycation; hemoglobin As; human tissue; insulin; miniature biomedical equipment; patient monitoring device; polymers; triglycerides

DESCRIPTION (provided by applicant): The applicant organization proposes to develop an ultra-miniaturized, minimally invasive diabetes monitoring system for estimating concentrations of diabetes-related parameters (analytes) in whole blood. The system is comprised of analyte specific test tabs and a hand-held meter. The test tabs dose and transport a blood sample in the nanoliter range (approximately 300nL) to an integrated polymeric detection site. The detection site embodies dried chemical reagents capable of reacting with analyte, as well as a polymeric composition capable of absorbing a defined volume of blood plasma while preventing cellular component of blood from penetrating the composition. Cells are wholly removed from the detection site by proprietary chemical and physical mechanisms, thereby obviating the need for a separate cell filtering material and unmasking the detection site for visual or instrumented analysis. Test procedure is streamlined and performance time drastically reduced by consolidating all testing steps into one single disposable device. Primary target markets are point-of-care and self-testing environments.

描述（由申请人提供）： 申请组织提议开发一种超小型、微创糖尿病监测系统，用于估计全血中糖尿病相关参数（分析物）的浓度。该系统由分析物特定测试标签和手持式仪表组成。测试片将纳升范围（约 300nL）的血液样本定量并输送至集成聚合物检测位点。检测位点包含能够与分析物反应的干燥化学试剂，以及能够吸收限定体积的血浆同时防止血液的细胞成分渗透该组合物的聚合物组合物。通过专有的化学和物理机制将细胞从检测部位完全去除，从而无需单独的细胞过滤材料并暴露检测部位以进行视觉或仪器分析。通过将所有测试步骤整合到一个一次性设备中，简化了测试程序并大大减少了执行时间。主要目标市场是现场护理和自我测试环境。