OptoAcoustic and Ultrasonic Imaging of Angiogenesis

血管生成的光声和超声成像

• 批准号: 6831222
• 负责人: WALTER G SCOTT
• 金额: $ 9.72万
• 依托单位: WINPROBE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-19 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831222
• 关键词: angiocardioultrasonography; angiogenesis; angiogenesis inhibitors; bioimaging /biomedical imaging; biomedical equipment development; fiber optics; image processing; laboratory mouse; lasers; light scattering; oxyhemoglobin; phantom model

DESCRIPTION (provided by applicant): This proposal for "Optoacoustic and Ultrasonic Imaging of Angiogenesis" combines optoacoustics and ultrasound in a single instrument for the first time. A I 2MHz phased array ultrasound probe equipped with fiber optics for delivery of laser illuminations will operate in the backwards mode. In this method the ultrasonic image and the optoacoustic image will be spatially overlaid and then fused in some presentations. The ultrasonic images will include B-Mode, color Flow Doppler, power Doppler and Spectral Doppler. A stacked transducer will double the acoustic spectral capabilities to 24 MHz on reception to attain visualization of very small vessels in the neovascuIarization. An OPO laser will provide a narrow wavelength from a spectrum of Infra Red wavelengths of light to photometrically select different compounds for light absorption, expansion and emission of ultrasound. Estimation of the oxy / deoxy hemoglobin in small vascular regions will be displayed as an image overlay. This unique instrument differentiates blood in optoacoustics, and tissue in ultrasound, allowing very high resolution of blood vessels, their flow (especially low flow without interference of wall motion) and their oxygen content. WinProbe's Scientific Research Platform will be optimized for this new combination of modalities and will produce fused images in real time. This proposal includes clinical studies to image and quantitatively access angiogenesis in mice under the effect of known anti-angiogenesis drugs. The goal is to commercialize an instrument for clinical research. The role of angiogenesis in cancer is well documented in the literature and this instrument can be expected to make a significant contribution to the science of cancer research. Future commercial products are expected to follow in endoscopic instruments to assist in the detection of cancer where optical assessments are limited to the surface and are contrast deprived.

描述（由申请人提供）： 这项“血管生成的光声和超声成像”提案首次将光声学和超声技术结合在一台仪器中。配备有用于传输激光照明的光纤的 1 2 MHz 相控阵超声探头将以反向模式运行。在这种方法中，超声图像和光声图像将在空间上重叠，然后在一些演示中融合。超声图像将包括 B 型、彩色血流多普勒、能量多普勒和频谱多普勒。堆叠式换能器将接收时的声谱能力加倍至 24 MHz，以实现新生血管中非常小的血管的可视化。 OPO 激光器将提供红外波长光谱中的窄波长，以光度选择不同的化合物来吸收、扩展和发射超声波。小血管区域中氧合/脱氧血红蛋白的估计将显示为图像叠加。 这种独特的仪器可以区分光声学中的血液和超声波中的组织，从而可以非常高分辨率地显示血管、血管流量（特别是在不干扰血管壁运动的情况下的低流量）及其含氧量。 WinProbe 的科学研究平台将针对这种新的模式组合进行优化，并将实时生成融合图像。 该提案包括在已知抗血管生成药物作用下对小鼠血管生成进行成像和定量评估的临床研究。目标是将临床研究仪器商业化。 血管生成在癌症中的作用在文献中有详细记载，预计该仪器将为癌症研究科学做出重大贡献。 未来的商业产品预计将在内窥镜仪器中使用，以协助检测癌症，其中光学评估仅限于表面并且缺乏对比度。