Integrated Multifunctional Imaging of Deep Vein Thrombosis

深静脉血栓形成的综合多功能成像

• 批准号: 7662486
• 负责人: WALTER G SCOTT
• 金额: $ 55.07万
• 依托单位: WINPROBE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-17 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7662486
• 关键词: Acoustics; Acute; Address; Advanced Development; Age; Aging; Algorithms; Anatomy; Animals; Anticoagulation; Arts; Biomechanics; Blood Clot; Blood Platelets; Blood coagulation; Businesses; Cessation of life; Chronic; Classification; Clinical; Clinical Engineering; Clinical Management; Clinical Protocols; Clinical Research; Coagulation Process; Color; Commit; Complication; Computer Systems Development; Computer software; Custom; Data; Deep Vein Thrombosis; Detection; Developed Countries; Developing Countries; Development; Diagnosis; Diagnostic Imaging; Diagnostic Procedure; Elasticity; Elements; Engineering; Erythrocytes; Fibrin; Goals; Gold; Hospital Mortality; Image; Imagery; Imaging Device; Imaging Techniques; Investigation; Laboratories; Lasers; Leukocytes; Low-Molecular-Weight Heparin; Maps; Marketing; Measures; Mechanics; Medical center; Methods; Michigan; Microsurgery; Modeling; Modification; Monitor; Morbidity - disease rate; Multimodal Imaging; Names; Neurofibrillary Tangles; Optics; Patients; Performance; Phase; Phase I Clinical Trials; Physiologic pulse; Postdoctoral Fellow; Principal Investigator; Procedures; Property; Pulmonary Embolism; Radiology Specialty; Research; Research Design; Research Personnel; Resolution; Risk; Signal Transduction; Small Business Innovation Research Grant; Source; Staging; Structure; System; Systems Integration; Techniques; Technology; Testing; Texas; Thrombus; Time; Tissues; Ultrasonic Transducer; Ultrasonics; Ultrasonography; United States; Universities; Venous; Work; absorption; anticancer research; austin; base; cellular imaging; commercialization; deep vein; design; experience; image processing; imaging modality; member; mortality; new technology; optical fiber; optical imaging; pre-clinical; professor; programs; prototype; radiologist; reconstruction; research clinical testing; skills; tool; treatment planning

DESCRIPTION (provided by applicant): Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries. Indeed, anywhere from 60,000 to 200,000 people are dying each year in the United States because of DVT related pulmonary embolism. Therefore, reliable detection and diagnosis of DVT is of paramount importance. Once detected, acute clots must be differentiated from chronic DVT for appropriate treatment. However, there are no reliable, clinically available methods to stage DVT. Even the gold standard diagnostic technique, duplex venous ultrasound, can only detect but not age these clots. Therefore once a DVT is detected, highly potent, low-molecular weight heparin anticoagulation therapy, with its associated morbidity and mortality, is often given to over compensate for a PE risk from what might only be a chronic thrombus. Over time, as a clot ages and matures, DVT consistently hardens. Previous studies demonstrated that elastography a technique to image elastic properties of tissue can be used to reliably differentiate the chronic and acute DVT. In addition to elasticity contrast, optical absorption of DVT changes with blood clot maturation the acute clots are associated with high concentration of red blood cells, and chronic composed of tangled mesh of platelets, fibrin, and degenerating leukocytes. Consequently, the photoacoustic imaging an ultrasound-based imaging of optical absorption can be used to further characterize blood clots thus assisting the classification of detected DVT. Therefore, we propose to develop an integrated multifunctional imaging system to simultaneously detect and differentiate DVT based on grayscale and Doppler/color flow ultrasound imaging, photoacoustic imaging and elastography. The combined imaging will enhance DVT detection, diagnosis and staging without significant modification in current clinical protocol of ultrasound examination of DVT. The main objective of this fast-track SBIR program is to develop and test the integrated ultrasound, photoacoustic and elasticity imaging system to detect and age DVT. To achieve our objective, we will design and build an ultrasound imaging system capable of simultaneous, real-time ultrasound, photoacoustic and strain imaging of blood clots in deep vein, and subsequent visualization of DVT elasticity. We will then test the developed system using tissue-mimicking models of DVT followed by clinical studies of patients with known acute and chronic blood clots. Based on the results of these studies, it is the long-range goal of the overall program to develop, thoroughly test and commercialize a real-time ultrasound-based imaging system for DVT detection, diagnosis and aging. The central theme of this project is to design, develop and commercialize a real-time integrated multimodal ultrasound-based imaging system to detect and age deep vein thrombosis. Our research program is focused on development of an advanced imaging tool that takes full advantage of the many synergistic features of three complementary imaging modalities ultrasound, photoacoustics, and elastography. Integrated ultrasound, photoacoustic and elasticity imaging is a novel technology capable of accurate visualization of both structural and functional properties of tissue and it may be useful far beyond DVT detection and diagnosis. The applications of multimodal imaging may be extended into cancer research, diagnostic imaging and therapy monitoring, cellular imaging, small animal imaging, microsurgery, etc. The current study, however, is a part of a focused program to develop and commercialize much needed yet unavailable clinical tool for DVT detection, diagnosis and characterization.

描述（由申请人提供）： 深静脉血栓（DVT）及其后遗症肺栓塞（PE）是一个重要的临床问题，是美国和其他发达国家可预防的院内死亡的主要原因。事实上，在美国，每年有 60,000 至 200,000 人死于与 DVT 相关的肺栓塞。因此，可靠的 DVT 检测和诊断至关重要。一旦检测到，必须将急性血栓与慢性 DVT 区分开来进行适当的治疗。然而，尚无可靠的临床可用方法来对 DVT 进行分期。即使是金标准诊断技术，双功静脉超声，也只能检测到这些血栓，而不能使其老化。因此，一旦检测到 DVT，通常会给予高效、低分子量肝素抗凝治疗，以过度补偿慢性血栓引起的肺栓塞风险，但会导致相关的发病率和死亡率。随着时间的推移，随着血栓的老化和成熟，深静脉血栓持续硬化。先前的研究表明，弹性成像技术是一种对组织弹性特性进行成像的技术，可用于可靠地区分慢性和急性 DVT。除了弹性对比外，DVT 的光吸收也会随着血块成熟而变化，急性血栓与高浓度的红细胞有关，而慢性血栓则由血小板、纤维蛋白和退化白细胞的缠结网组成。因此，光声成像和基于超声的光吸收成像可用于进一步表征血凝块，从而有助于对检测到的 DVT 进行分类。因此，我们建议开发一种集成的多功能成像系统，基于灰度和多普勒/彩色血流超声成像、光声成像和弹性成像，同时检测和区分 DVT。组合成像将增强 DVT 的检测、诊断和分期，而无需对当前 DVT 超声检查的临床方案进行重大修改。该快速 SBIR 项目的主要目标是开发和测试集成超声、光声和弹性成像系统，以检测 DVT 并使其老化。为了实现我们的目标，我们将设计和构建一个超声成像系统，能够对深静脉血栓进行同步实时超声、光声和应变成像，并随后实现 DVT 弹性的可视化。然后，我们将使用 DVT 组织模拟模型测试开发的系统，然后对患有已知急性和慢性血栓的患者进行临床研究。基于这些研究的结果，整个计划的长期目标是开发、彻底测试和商业化用于 DVT 检测、诊断和老化的实时超声成像系统。该项目的中心主题是设计、开发和商业化基于实时集成多模态超声的成像系统，以检测深静脉血栓并使其老化。我们的研究项目专注于开发一种先进的成像工具，该工具充分利用超声波、光声学和弹性成像这三种互补成像模式的许多协同特征。集成超声、光声和弹性成像是一项新技术，能够准确可视化组织的结构和功能特性，其用途可能远远超出 DVT 检测和诊断。多模态成像的应用可以扩展到癌症研究、诊断成像和治疗监测、细胞成像、小动物成像、显微外科手术等。然而，当前的研究是一个重点计划的一部分，该计划旨在开发和商业化急需但不可用的技术DVT 检测、诊断和表征的临床工具。