Assessment Of Patients With Lyme Infection

莱姆病感染患者的评估

• 批准号: 7194103
• 负责人: ADRIANA R MARQUES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7194103
• 关键词: Borrelia; Lyme disease; audiometry; bacteria infection mechanism; biomarker; children; chronic disease /disorder; communicable disease diagnosis; diagnosis design /evaluation; disease /disorder etiology; emerging infectious disease; host organism interaction; human subject; human therapy evaluation; magnetic resonance imaging; medical complication; microarray technology; microorganism disease chemotherapy; microorganism immunology; molecular pathology; neuropsychological tests; pathologic process; patient oriented research; polymerase chain reaction

Lyme disease is a multisystem illness caused by infection with the spirochete Borrelia burgdorferi and it is the leading vector-borne disease in the United States. Lyme disease is also common in Europe and also occurs in Russia, China and Japan. In humans, B. burgdorferi infection causes infection primarily in the skin, nervous system, heart and joints. Lyme disease can usually be treated successfully with antibiotic therapy, with the best results seen in patients with early disease. Unfortunately, some patients may not have a complete response to therapy. We currently have three clinical protocols studying patients with Lyme disease. Two protocols are natural history studies and serve as the basis for multiple lines of investigation. One protocols addresses patients with post treatment Lyme disease syndrome. The other protocol allow for the study of patients with classical Lyme disease. A third protocol will examine the host reponse in skin biopsies from patients with erythema migrans lesions using microarrays. Our work addresses 3 areas in Lyme disease: laboratory diagnosis, clinical manifestations and immunological responses to B. burgdorferi.

莱姆病是由螺旋体伯氏伯氏菌感染引起的多系统疾病，它是美国领先的媒介传播疾病。莱姆病在欧洲也很常见，也发生在俄罗斯，中国和日本。在人类中，伯氏芽孢杆菌感染主要在皮肤，神经系统，心脏和关节中引起感染。莱姆病通常可以通过抗生素疗法成功治疗，在早期疾病患者中可以看到最好的结果。不幸的是，有些患者可能对治疗没有完全反应。我们目前有三个研究莱姆病患者的临床方案。两个方案是自然史研究，并作为多项研究的基础。一种方案解决了治疗后莱姆病综合征的患者。另一项方案允许研究经典莱姆病患者。第三个方案将检查使用微阵列的红斑迁移患者的皮肤活检中的宿主响应。我们的工作解决了莱姆病的3个领域：实验室诊断，临床表现和对伯格多尔河芽孢杆菌的免疫反应。