Assessment Of Patients With Borrelia Infection

疏螺旋体感染患者的评估

基本信息

批准号：
10692041
负责人：
ADRIANA R MARQUES
金额：
$ 69.43万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10692041
关键词：
Acute Address Adrenal Cortex Hormones Aftercare Anaplasma phagocytophilum Antibiotic Therapy Antibiotics Antibodies Antibody Response Area Arthralgia Attention Babesia microti Biological Markers Borrelia Infections Borrelia burgdorferi COVID-19 Case Study Characteristics Clinical Clinical Protocols Clinical Research Constitutional Symptom Development Early Diagnosis Environment Europe Exposure to Facial paralysis Fatigue Frequencies Growth Headache Health Heart Human Immune response Individual Infection Investigation Joints Longitudinal cohort study Lyme Disease Lyme Neuroborreliosis Lyme disease diagnosis Memory Mus Myalgia Names Neck Nervous System Order Spirochaetales Outcome Paresthesia Patients Peptides Phospholipids Play Primary Infection Publications Publishing Recording of previous events Recovery Research Role Series Serology Skin Sleep Disorders Symptoms Syndrome System Testing Tick-Borne Diseases Tick-Borne Infections Ticks United States Work antibody detection biobank clinical database cohort erythema migrans pathogen persistent symptom recruit response skin lesion sleep difficulty tick bite tick-borne pathogen tool treatment response

Acute Address Adrenal Cortex Hormones Aftercare Anaplasma phagocytophilum Antibiotic Therapy Antibiotics Antibodies Antibody Response Area Arthralgia Attention Babesia microti Biological Markers Borrelia Infections Borrelia burgdorferi COVID-19 Case Study Characteristics Clinical Clinical Protocols Clinical Research Constitutional Symptom Development Early Diagnosis Environment Europe Exposure to Facial paralysis Fatigue Frequencies Growth Headache Health Heart Human Immune response Individual Infection Investigation Joints Longitudinal cohort study Lyme Disease Lyme Neuroborreliosis Lyme disease diagnosis Memory Mus Myalgia Names Neck Nervous System Order Spirochaetales Outcome Paresthesia Patients Peptides Phospholipids Play Primary Infection Publications Publishing Recording of previous events Recovery Research Role Series Serology Skin Sleep Disorders Symptoms Syndrome System Testing Tick-Borne Diseases Tick-Borne Infections Ticks United States Work antibody detection biobank clinical database cohort erythema migrans pathogen persistent symptom recruit response skin lesion sleep difficulty tick bite tick-borne pathogen tool treatment response

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项目摘要

Tickborne diseases are a serious health threat that has steadily risen, with reported cases more than doubling over the past 13 years. Lyme disease, or Lyme borreliosis, accounts for more than 80% of the reported cases of tickborne diseases in the US. It is estimated that over 476,000 cases of Lyme disease diagnosed and treated per year in the US, and over 200,000 cases estimated in Europe. Our current work addresses the following areas in Lyme disease: development of new tests and biomarkers for infection, investigation of persistence of infection with B. burgdorferi in humans, and investigation of the role of immune response in Lyme disease and post treatment Lyme disease syndrome (PTLDS). We have three clinical protocols exploring diverse aspects of Lyme disease and tickborne infections that are currently open to recruitment. In these, and past clinical studies, we have evaluated more than 800 patients. Together with this large clinical database, we have assembled a large biorepository that has served to explore multiple avenues of research in Lyme borreliosis and tickborne diseases. In the past year, have a series of publications. We described the characteristics of patients with early Lyme neuroborreliosis presenting with facial palsy in our cohort, pointing attention to important clues in the history (exposure to ticks in an endemic area, but not necessarily a history of recognized tick bite, constitutional symptoms and/or skin lesions, and presentation in the summer months) that help with early diagnosis. Most patients had an excellent recovery, and the recovery was similar for patients who received antibiotics alone or both antibiotics and corticosteroids. In another publication, we showed that B. burgdorferi, which can accumulate intact phospholipids from its environment to support growth, and that antibody responses to host phospholipids occur in mice and patients with acute Lyme disease. Further study will be required to determine whether these antibodies have utility in early diagnosis of Lyme disease, tracking of the response to therapy. We have also help study the serologic response to Anaplasma phagocytophilum and Babesia microti, two emerging tick-borne pathogens in the United States. Using a peptide array to select sets of linear peptides, we identified peptides that can be a useful tool for detection of antibody reactivity to both of these pathogens. We have also helped with a longitudinal cohort study to characterize the clinical sequelae and persistent symptoms after COVID-19. The initial findings of this study have been published.

Tickborne疾病是一种严重的健康威胁，稳步上升，据报道，在过去的13年中，案件增加了一倍以上。莱姆病（莱姆病）或莱姆毛毛病（Lyme Borreliosis）占美国报道的tick骨疾病病例的80％以上。据估计，在美国，每年诊断和治疗的莱姆病超过476,000例，在欧洲估计超过200,000例病例。我们目前的工作涉及莱姆病的以下领域：开发新的测试和生物标志物，用于感染的新测试和生物标志物，调查人类中伯格多菲利的感染持续性，以及对莱姆病在莱姆病中的作用和治疗后莱姆病疾病综合征（PTLD）的作用。我们有三个临床方案，探讨了目前曾易招募的莱姆病和tick虫感染的各个方面。在这些和过去的临床研究中，我们评估了800多名患者。与这个大型临床数据库一起，我们组装了一个大型的生物库，该生物座探索了莱姆毛促性疾病和tick虫疾病的多种研究途径。在过去的一年中，有一系列出版物。我们描述了莱姆神经性早期神经性病的患者的特征，在我们的队列中表现出面部麻痹，将注意力集中在历史上的重要线索（暴露于地方性区域的壁虱中，但不一定是公认的tick虫咬伤，宪法症状和/或皮肤病变的病史，以及在夏季诊断的疾病）。大多数患者的恢复良好，单独接受抗生素或抗生素和皮质类固醇的患者的恢复相似。在另一份出版物中，我们表明，B. burgdorferi可以从其环境中积累完整的磷脂以支持生长，并且对宿主磷脂的抗体反应发生在小鼠和急性莱姆病的患者中。将需要进一步的研究来确定这些抗体在早期诊断莱姆病的早期诊断中是否具有效用，并跟踪对治疗的反应。我们还帮助研究了对美国两种新兴的tick传播病原体的吞噬细胞吞噬和贝贝西亚微动物的血清学反应。使用肽阵列选择一组线性肽，我们确定了可以检测对这两种病原体抗体反应性的有用工具的肽。我们还帮助进行了一项纵向队列研究，以表征Covid-19之后的临床后遗症和持续性症状。这项研究的最初发现已发表。