Mentoring Junior Faculty: Access to HIV Care

指导初级教师：获得艾滋病毒护理

• 批准号: 7061237
• 负责人: Andrew H Kaplan
• 金额: $ 3.93万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-10 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7061237
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; behavioral /social science research tag; clinical research; combination chemotherapy; correctional institutions; drug resistance; education evaluation /planning; gene mutation; geographic difference; health behavior; health care service availability; health services research tag; host organism interaction; human immunodeficiency virus 1; interview; patient oriented research; protein structure; socioeconomics; therapy compliance; training; virulence; virus genetics; virus replication

DESCRIPTION (provided by applicant): The introduction of combination anti-HIV therapy has produced dramatic declines in mortality and morbidity among people with HIV. Unfortunately, a significant number of patients will experience a rebound in their disease within two years of starting therapy. In many cases this virologic failure is associated with the appearance of HIV variants encoding mutations that render them resistant to the available therapies. Of additional concern is the observation that these resistant variants are found with some frequency in newly infected individuals who have never received therapy, indicating that they can spread from one person to another. This development and subsequent dissemination of resistant viruses reflects a complicated interplay among aspects of the molecular biology of HIV, the behavior of HIV-infected people and the economic and social conditions in which people with H/V/AIDS find themselves. The research goals of this proposal are to address the question "What types of behaviors are most likely to lead to the failure of combination antiretroviral therapy?" Through these studies, I will begin to integrate my laboratory, health services and social science research interests. My mentoring goals are to: 1) Provide training and support to trainees and junior faculty as they advance to research independence 2) Develop a research curriculum related to behavioral medicine. I will devote particular attention to advancing my expertise in psychometric studies. The K24 award will allow me protected time and resources to explore this series of projects and to mentor the next generation of clinical researchers.

描述（由申请人提供）：引入抗HIV疗法的联合疗法引起了艾滋病毒患者的死亡率和发病率的急剧下降。不幸的是，在开始治疗后的两年内，大量患者会经历疾病的反弹。在许多情况下，这种病毒学衰竭与编码突变的HIV变体的出现有关，使它们对可用疗法有抵抗力。另一个问题是，在从未接受过治疗的新受感染者中发现了这些抗性变体的某种频率，表明他们可以从一个人传播到另一个人。这种抗性病毒的发展和随后的传播反映了艾滋病毒分子生物学的各个方面，艾滋病毒感染者的行为以及h/v/aids患者找到自己的经济和社会状况的各个方面。该提案的研究目标是解决一个问题：“哪种类型的行为最有可能导致抗逆转录病毒疗法的失败？”通过这些研究，我将开始整合我的实验室，卫生服务和社会科学研究的兴趣。 我的指导目标是：1）在研究独立性时向受训者和初级教师提供培训和支持2）开发与行为医学有关的研究课程。我将特别关注在心理测量研究方面提高我的专业知识。 K24奖将使我保护时间和资源来探索这一系列项目，并指导下一代临床研究人员。