Spatiotemporal ERP Modeling & Brain Development

时空 ERP 建模

• 批准号: 7111156
• 负责人: JOSEPH R ISLER
• 金额: $ 17.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111156
• 关键词: baboons; brain; clinical research; computational biology; computational neuroscience; computer data analysis; computer simulation; developmental neurobiology; electroencephalography; embryo /fetus; evoked potentials; human subject; infant animal; mature animal; method development; neurogenesis; postdoctoral investigator; training

DESCRIPTION (provided by applicant): The candidate for the award is a PhD atmospheric physicist seeking to redirect his career into quantitative research in neuroscience. He was a highly productive NSF funded investigator in atmospheric dynamics. With his strong background in physics, nonlinear dynamics, time series analysis, applied mathematics and computer simulations of complex systems he has already made remarkable strides in pursuit of this new career. During his post-doctoral fellowship in developmental psychobiology, he has demonstrated a strong potential to be a significant member of a multi-disciplinary team and a definite commitment to quantitative neuro-developmental research, witnessed by his contributions to the literature and extensive initial results. The scientific objective of the award is to develop new quantitative methods of analysis for event related potential (ERP) experiments performed in adults, infants and fetal primates, and then to link these experimental results to computational neural models that will simulate development of the underlying neural systems. Specific hypotheses regarding source networks of the MMN (mismatch negativity) and P3a "oddball" ERP components will be tested with the new methods. Results should lead to the development of new clinical and diagnostic tools that assess the integrity of cortical function in infants and non-responsive adults. His career award plan has been carefully structured to substantially contribute to his scientific development. His has unique needs that will be met with specific clinical and didactic resources and formal course work including a seminar in responsible conduct of research. He will be conscientiously mentored with guidance and advice from a team of individuals chosen for their interests in collaboration and availability, appropriateness of expertise and resources, and previous success in fostering the progress of researchers.

描述（由申请人提供）：该奖项的候选人是一位大气物理学家，试图将自己的职业重定向到神经科学的定量研究中。他是大气动力学高产的NSF资助研究者。他的物理学，非线性动力学，时间序列分析，应用数学和计算机模拟的复杂系统的强大背景，他已经在追求这一新职业方面取得了长足的进步。在他的发育心理生物学博士学位奖学金期间，他表现出了很大的潜力，可以成为多学科团队的重要成员，并坚定地致力于定量神经发展研究，这是他对文学的贡献和广泛的初步结果所见证的。该奖项的科学目标是为成人，婴儿和胎儿灵长类动物进行事件相关潜力（ERP）实验的新定量分析方法，然后将这些实验结果与计算神经模型联系起来，以模拟基本神经系统的发展。有关MMN的源网络（不匹配负性）和P3A“ ODDBALL” ERP组件的特定假设将使用新方法进行测试。结果应导致开发新的临床和诊断工具，以评估婴儿和无反应性成年人皮质功能的完整性。他的职业奖计划经过精心构建，为他的科学发展做出了重大贡献。他的独特需求将满足特定的临床和教学资源以及正式课程工作，包括负责研究的研讨会。他将认真指导他的指导和建议，这些团队因其在协作和可用性，专业知识和资源的适当性以及以前在促进研究人员进步方面的成功而被选为他们的利益，适当的人。