Spatiotemporal ERP Modeling & Brain Development

时空 ERP 建模

• 批准号: 6958195
• 负责人: JOSEPH R ISLER
• 金额: $ 16.61万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958195
• 关键词: baboons; brain; clinical research; computational biology; computational neuroscience; computer data analysis; computer simulation; developmental neurobiology; electroencephalography; embryo /fetus; evoked potentials; human subject; infant animal; mature animal; method development; neurogenesis; postdoctoral investigator; training

DESCRIPTION (provided by applicant): The candidate for the award is a PhD atmospheric physicist seeking to redirect his career into quantitative research in neuroscience. He was a highly productive NSF funded investigator in atmospheric dynamics. With his strong background in physics, nonlinear dynamics, time series analysis, applied mathematics and computer simulations of complex systems he has already made remarkable strides in pursuit of this new career. During his post-doctoral fellowship in developmental psychobiology, he has demonstrated a strong potential to be a significant member of a multi-disciplinary team and a definite commitment to quantitative neuro-developmental research, witnessed by his contributions to the literature and extensive initial results. The scientific objective of the award is to develop new quantitative methods of analysis for event related potential (ERP) experiments performed in adults, infants and fetal primates, and then to link these experimental results to computational neural models that will simulate development of the underlying neural systems. Specific hypotheses regarding source networks of the MMN (mismatch negativity) and P3a "oddball" ERP components will be tested with the new methods. Results should lead to the development of new clinical and diagnostic tools that assess the integrity of cortical function in infants and non-responsive adults. His career award plan has been carefully structured to substantially contribute to his scientific development. His has unique needs that will be met with specific clinical and didactic resources and formal course work including a seminar in responsible conduct of research. He will be conscientiously mentored with guidance and advice from a team of individuals chosen for their interests in collaboration and availability, appropriateness of expertise and resources, and previous success in fostering the progress of researchers.

描述（由申请人提供）：该奖项的候选人是一位大气物理学博士，寻求将自己的职业生涯转向神经科学的定量研究。他是一位高产的美国国家科学基金会资助的大气动力学研究员。凭借他在物理学、非线性动力学、时间序列分析、应用数学和复杂系统计算机模拟方面的深厚背景，他在追求这一新职业的过程中已经取得了显着的进步。在发育心理生物学博士后研究期间，他表现出了成为多学科团队重要成员的强大潜力，以及对定量神经发育研究的明确承诺，他对文献的贡献和广泛的初步结果证明了这一点。该奖项的科学目标是为在成人、婴儿和胎儿灵长类动物中进行的事件相关电位（ERP）实验开发新​​的定量分析方法，然后将这些实验结果与计算神经模型联系起来，该模型将模拟潜在神经元的发育。系统。有关 MMN（失配负性）和 P3a“奇怪”ERP 组件的源网络的具体假设将使用新方法进行测试。结果应导致新的临床和诊断工具的开发，以评估婴儿和无反应的成人皮质功能的完整性。他的职业奖励计划经过精心设计，为他的科学发展做出了重大贡献。他有独特的需求，可以通过特定的临床和教学资源以及正式的课程作业（包括负责任的研究行为研讨会）来满足。他将受到一个团队的认真指导和建议，该团队的成员是根据他们对协作和可用性、专业知识和资源的适当性以及以前在促进研究人员进步方面的成功的兴趣而选择的。