ACR RE-CLASSIFICATION OF SLE CRITERIA (AROSE) ORIG GRANT REVISION OF ACR CLASSIF

ACR SLE 标准重新分类 (AROSE) 原始拨款修订 ACR 分类

• 批准号: 7380477
• 负责人: Graciela S Alarcon
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380477
• 关键词: ACR; RE; CLASSIFICATION; SLE; CRITERIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) have proven to be inadequate in the current research climate. The current criteria over-represent cutaneous lupus, with 4 criteria (whereas every other organ receives only 1). The current criteria need to be updated to represent advances in serologic testing (e.g., complement components, new autoantibodies), improved diagnostic and laboratory testing (e.g., renal biopsy findings, urine protein to creatinine ratios) and broader definitions of organ involvement (e.g., redefining neurologic involvement as more than "seizures" or "psychosis"). The Systemic Lupus International Collaborating Clinics (SLICC) has set a standard for cooperation and productivity in the development and validation of clinical trial measures for SLE, including the SLE Disease Activity lndex (SLDEAI), the SLlCC Damage lndex (later also adopted by the ACR), and the SF-36. SLlCC consists of nearly 30 academic centers world-wide. In this study, SLlCC will: 1)identify, by frequency analysis, the feasibility of proposed classification criteria; 2) sequentially enroll SLE patients and those with related diseases into a systematic protocol to test proposed classification criteria using traditional and classification tree methodology; and 3) participate in a validation exercise of the generated classification criteria in a new set of patients.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。现任美国风湿病学院（ACR）全身性红斑狼疮（SLE）的分类标准已被证明在当前的研究氛围中是不足的。当前的标准超出了皮肤狼疮，标准为4个标准（而其他每个器官仅收到1个标准）。需要更新当前的标准以表示血清学测试的进步（例如，补体组件，新自身抗体），改进的诊断和实验室测试（例如，肾脏活检发现，尿液蛋白与肌酐比率）以及更广泛的器件介绍（例如，更广泛的神经学介绍）或更广泛的神经学涉及的定义或更广泛的定义。全身性狼疮国际合作诊所（SLICC）为SLE的临床试验措施开发和验证的合作和生产力标准，包括SLE病疾病活动LNDEX（SLDEAI），SLLCC损害LNDEX（后来由ACR）和SF-36采用。 SLLCC由全球近30个学术中心组成。在这项研究中，SLLCC将：1）通过频率分析确定拟议分类标准的可行性； 2）依次招募SLE患者和患有相关疾病的患者进入系统方案，以使用传统和分类树方法测试建议的分类标准； 3）参与一组新患者的验证练习生成的分类标准。