Local Telemetry System for Microelectrode Recording

用于微电极记录的本地遥测系统

• 批准号: 7052575
• 负责人: Kenneth Shane Guillory
• 金额: $ 9.88万
• 依托单位: RIPPLE, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-15 至 2007-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052575
• 关键词: biomedical device power system; biomedical equipment development; computer program /software; electrophysiology; microelectrodes; miniature biomedical equipment; nervous system prosthesis; neurosciences; telemetry

DESCRIPTION (provided by applicant): The goal of this program is to create miniature, low-power neural signal recording headstages with short-range digital RF telemetry. These systems will provide untethered recording capabilities for up to 128 extracellular microelectrodes for animals as small as mice and rats, and up to 256 channels for larger animals. The systems will also allow recording of both local field potentials and extracellular spikes. The devices will use an innovative combination of custom analog ASIC and commercial digital components. In Phase I, the feasibility of the technical approach will be demonstrated by building functional 32-channel systems. In Phase II, these devices will be finished as products for the neuroscience research community. The final base station receiver will be highly programmable to allow use of the system with stand-alone PCs and/or other third-party neural signal processing systems. The real-time interface and PC processing software will be made available as Open Source to facilitate easy customization. These systems will improve the convenience of neuroscience experiments with microelectrode arrays, and enable data from large numbers of electrodes to be collected in free-moving and behaving animals. This project will indirectly support public health by improving the flexibility, quality and efficiency of experiments used for neuroscience and neuroprosthesis research.

描述（由申请人提供）：该计划的目标是创建具有短程数字射频遥测功能的微型、低功耗神经信号记录探头。这些系统将为小鼠和大鼠等小型动物提供多达 128 个细胞外微电极，为较大动物提供多达 256 个通道的不受限制的记录功能。该系统还将允许记录局部场电位和细胞外尖峰。这些器件将采用定制模拟 ASIC 和商业数字组件的创新组合。在第一阶段，将通过构建功能性 32 通道系统来证明该技术方法的可行性。在第二阶段，这些设备将作为神经科学研究界的产品完成。最终的基站接收器将具有高度可编程性，以允许该系统与独立 PC 和/或其他第三方神经信号处理系统一起使用。实时界面和PC处理软件将作为开源提供，以方便定制。这些系统将提高微电极阵列神经科学实验的便利性，并能够在自由移动和行为的动物中收集大量电极的数据。该项目将通过提高神经科学和神经假体研究实验的灵活性、质量和效率来间接支持公共健康。