HIGH RESOLUTION NUCLEAR CARDIAC IMAGING

高分辨率核心脏成像

• 批准号: 7050314
• 负责人: GERALD ENTINE
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7050314
• 关键词: bioimaging /biomedical imaging; bromine; cardiovascular disorder diagnosis; cesium; computed axial tomography; coronary disorder; crystallization; gamma radiation; heart imaging /visualization /scanning; light emission; nuclear medicine; positron emission tomography; radiotracer; scintillation counter; single photon emission computed tomography; technology /technique development

DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a radionuclide in any slice through an organ under study in the body [Phelps]. These images allow investigation of metabolism in the region being studied and are a useful tool for understanding the functioning of the organs as well as diagnosing symptoms of diseases. Nuclear medicine is a very important modality in cardiac imaging, providing both diagnosis as well as prognosis. SPECT is commonly used in localizing coronary artery disease and as many as 90% of myocardial perfusion studies are now performed using SPECT. The role of PET in cardiac imaging is gradually expanding, particularly in the areas of detecting coronary artery disease (where it shows -10 to 15% higher accuracy then SPECT) and assessing myocardial viability [Gunn Bronson]. Recent developments in combining nuclear medicine with X-ray CT imaging provide better attenuation correction in cardiac imaging studies. It is clear that nuclear medicine technologies are playing a prominent and an increasingly important role in cardiac care and clinical diagnosis. However, there is urgent need for improvement in the performance of these imaging modalities in order to exploit their full potential. The goal of the proposed effort is to investigate a new high resolution detector for nuclear medicine.

描述（由申请人提供）：单光子发射计算机断层扫描 (SPECT) 和正电子发射断层扫描 (PET) 等核医学成像模式是强大的非侵入性医学成像技术，可提供放射性核素的三维分布图像。体内正在研究的器官的任何切片[菲尔普斯]。这些图像可以对所研究区域的新陈代谢进行调查，并且是了解器官功能以及诊断疾病症状的有用工具。核医学是心脏成像的一种非常重要的方式，可提供诊断和预后。 SPECT 通常用于定位冠状动脉疾病，现在多达 90% 的心肌灌注研究都是使用 SPECT 进行的。 PET 在心脏成像中的作用正在逐渐扩大，特别是在检测冠状动脉疾病（其准确度比 SPECT 高 -10% 到 15%）和评估心肌活力方面 [Gunn Bronson]。核医学与 X 射线 CT 成像相结合的最新进展为心脏成像研究提供了更好的衰减校正。显然，核医学技术在心脏护理和临床诊断中发挥着突出且日益重要的作用。然而，迫切需要改进这些成像方式的性能，以充分发挥其潜力。拟议工作的目标是研究一种用于核医学的新型高分辨率探测器。