STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY

刺激增强运动和神经运动治疗

• 批准号: 7051657
• 负责人: Eric C Hartman
• 金额: $ 10万
• 依托单位: CUSTOMKYNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051657
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical research; computer human interaction; computer program /software; electronic stimulator; electrostimulus; exercise; human subject; human therapy evaluation; information display; medical rehabilitation related tag; nervous system disorder therapy; neuromuscular stimulator; paralysis; physical therapy; spinal cord injury; therapy design /development

DESCRIPTION (provided by applicant): This project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower extremity exercise that has the potential to increase muscle mass, strength, and endurance, and may additionally reverse or slow the rate of loss of bone mineral density. The user will be encouraged to voluntarily perform the exercise, which will be augmented with electrical stimulation to complete the prescribed exercise range of motion. The stimulation controller will continuously adjust the stimulation profile to provide only the stimulation that is necessary to complete the exercise while encouraging the user to contribute their best volitional effort on each exercise cycle. We hypothesize that this exercise may provide motor retraining benefits to some users in addition to exercising lower extremity muscles and bones. In Phase I, we propose: 1) to modify our existing adaptive stimulation controller for use by individuals with iSCI who have the ability to voluntarily active the stimulated muscles, 2) to develop a simple visual feedback display to facilitate coordination between the user and stimulation controller, 3) to validate the display paradigm in a study with subjects without neuromotor deficits, and 4) to demonstrate feasibility of our approach by testing the device in a study with subjects with iSCI. In Phase II, we will further develop the adaptive stimulation controller, develop simple, user-friendly visual feedback paradigms to improve user/stimulation coordination, and demonstrate efficacy of the approach in a long-term study where individuals with incomplete SCI use the device in a motor retraining setting. The target market for the device is clinics who serve individuals with neuromotor disabilities such as incomplete SCI, traumatic brain injury, or stroke. The device will be competitively priced within the electrical stimulation-based exercise equipment market. RELEVANCE TO PUBLIC HEALTH: This project in relevant to public health because it may lead to development of a practical exercise device for individuals with iSCI that may prolong the onset of osteoporosis in the long bones of the legs and may lead to improved voluntary control of paralyzed lower extremity muscles when used as one component of a comprehensive post-SCI rehabilitation program.

描述（由申请人提供）：该项目拟为不完全脊髓损伤（iSCI）患者开发一种电刺激增强运动装置。该设备将提供闭链、负重下肢锻炼，有可能增加肌肉质量、力量和耐力，还可以逆转或减缓骨矿物质密度的损失速度。将鼓励用户自愿进行锻炼，并通过电刺激来增强锻炼，以完成规定的锻炼运动范围。刺激控制器将不断调整刺激曲线，以仅提供完成锻炼所需的刺激，同时鼓励用户在每个锻炼周期中贡献出最佳的意志力。我们假设，除了锻炼下肢肌肉和骨骼之外，这种练习还可以为一些用户提供运动再训练的好处。在第一阶段，我们建议：1）修改我们现有的自适应刺激控制器，供有能力自愿激活受刺激肌肉的 iSCI 个体使用，2）开发简单的视觉反馈显示，以促进用户和刺激之间的协调控制器，3）在没有神经运动缺陷的受试者的研究中验证显示范例，4）通过在患有 iSCI 的受试者的研究中测试设备来证明我们的方法的可行性。在第二阶段，我们将进一步开发自适应刺激控制器，开发简单、用户友好的视觉反馈范例以改善用户/刺激协调，并在长期研究中证明该方法的有效性，其中不完全 SCI 的个体在运动再训练设置。该设备的目标市场是为患有神经运动障碍（例如不完全性 SCI、创伤性脑损伤或中风）的患者提供服务的诊所。该设备在基于电刺激的运动设备市场上的价格将具有竞争力。 与公众健康的相关性：该项目与公众健康相关，因为它可能会导致为 iSCI 患者开发一种实用的运动装置，该装置可能会延长腿部长骨骨质疏松症的发作时间，并可能导致改善瘫痪的自主控制下肢肌肉作为综合性脊髓损伤后康复计划的一部分。