Mechanisms of GnRH Neuron Migration During Development

发育过程中 GnRH 神经元迁移的机制

• 批准号: 6755117
• 负责人: GERALD A SCHWARTING
• 金额: $ 31.39万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755117
• 关键词: axon; cell adhesion molecules; cell migration; complementary DNA; developmental neurobiology; gamma aminobutyrate; genetic promoter element; genetically modified animals; gonadotropin releasing factor; green fluorescent proteins; laboratory mouse; neuronal guidance; neurons; olfactory nerve; prosencephalon; recombinant proteins; tissue /cell culture; video microscopy; vomeronasal systems

项目成果

Overexpression of glutamic acid decarboxylase-67 (GAD-67) in gonadotropin-releasing hormone neurons disrupts migratory fate and female reproductive function in mice.

促性腺激素释放激素神经元中谷氨酸脱羧酶 67 (GAD-67) 的过度表达会破坏小鼠的迁徙命运和雌性生殖功能。

• DOI: 10.1210/en.2002-221107
• 发表时间: 2003-06-01
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: S. Heger;M. Seney;E. Bless;G. Schwarting;Marie Bilger;A. Mungenast;S. Ojeda;S. Tobet
• 通讯作者: S. Tobet

The spatial relationship of gamma-aminobutyric acid (GABA) neurons and gonadotropin-releasing hormone (GnRH) neurons in larval and adult sea lamprey, Petromyzon marinus.

幼虫和成年海七鳃鳗 (Petromyzon marinus) 中γ-氨基丁酸 (GABA) 神经元和促性腺激素释放激素 (GnRH) 神经元的空间关系。

• 发表时间: 2002
• 作者: Reed, Karen L;MacIntyre, Janet K;Tobet, Stuart A;Trudeau, Vance L;MacEachern, Lisa;Rubin, Beverly S;Sower, Stacia A
• 通讯作者: Sower, Stacia A

Gonadotropin-releasing hormone neuronal migration.

促性腺激素释放激素神经元迁移。

• DOI: 10.1055/s-2007-984736
• 发表时间: 2007-09-01
• 期刊: Seminars in reproductive medicine
• 影响因子: 2.7
• 作者: G. Schwarting;M. Wierman;S. Tobet
• 通讯作者: S. Tobet

Myocyte enhancer factors-2B and -2C are required for adhesion related kinase repression of neuronal gonadotropin releasing hormone gene expression.

肌细胞增强因子-2B 和-2C 是神经元促性腺激素释放激素基因表达的粘附相关激酶抑制所必需的。

• 发表时间: 2000-12-15
• 作者: Allen, M P;Xu, M;Zeng, C;Tobet, S A;Wierman, M E
• 通讯作者: Wierman, M E

Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse.

成年小鼠促性腺激素释放激素神经元中氯化钾协同转运蛋白 KCC2 的异质表达。

• 发表时间: 2003-07
• 作者: Leupen, Sarah M;Tobet, Stuart A;Crowley Jr, W F;Kaila, Kai
• 通讯作者: Kaila, Kai