Microarray Center for Research on the Nervous System

神经系统微阵列研究中心

• 批准号: 6937439
• 负责人: Dietrich A Stephan
• 金额: $ 136.82万
• 依托单位: TRANSLATIONAL GENOMICS RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6937439
• 关键词: Internet; biomedical facility; biomedical resource; cooperative study; data management; experimental designs; functional /structural genomics; health science research support; information dissemination; microarray technology; nervous system

DESCRIPTION (provided by applicant): The Translational Genomics Research Institute (TGen), a current NINDS NIMH Microarray Consortium center, offers this renewal application. The highest quality assistance with experimental design, data generation, data interpretation, and data dissemination will be provided. TGen already fulfills these functions for NINDS and NIMH extramural investigators/consortia, and has well-established protocols, web site and data repository, and bioinformatic methods which permit a high degree of throughput at low cost. The TGen center team are uniquely qualified because we have amassed significant expertise through 1) having performed this identical function as a consortium site for the past two years, 2) becoming a "Center of Excellence" for Affymetrix technology, 3) development of the consortium web portal (arrayconsortium.tgen.org) for tutorials, transparent work-flow management and progress monitoring, role dependent information access, and data dissemination, 4) ensuring MIAME compliant data and building the first MAGE-ML translation engine for HIPAA-compliant data sharing, 5) being well-versed in expression technology (Dr. Jeffrey Trent was involved in developing array technologies and the PI working with Affymetrix technology for the past seven years), 6) having performed over 2635 Affymetrix array experiments for the consortium in its first two years and receiving excellent reviews, 7) operation of the TGen center with a business infrastructure, and 8) having Dr. Stephan Chair the consortium for its entire 3 year existence. We propose to continue operating our NINDS NIMH Microarray Center. The proposed structure/function is anchored in experience, except for the R&D portions of the proposal. The goals include: 1) tutorials and project submission via the web, 2) review by an internal review committee with neuroscience experience, 3) standardized pricing for services across the consortium, 4) data generation on Affymetrix stock chips and analysis, 5) data warehousing with 6 month timed release to the public, and 6) technology development.

描述（由申请人提供）： 当前NINDS NIMH微阵列联盟中心转化基因组学研究所（TGEN）提供了此更新应用。将提供实验设计，数据生成，数据解释和数据传播的最高质量援助。 TGEN已经为Ninds和NIMH外校外研究人员/财团履行了这些功能，并且具有良好的协议，网站和数据存储库以及生物信息学方法，这些方法允许以低成本的高度吞吐量。 The TGen center team are uniquely qualified because we have amassed significant expertise through 1) having performed this identical function as a consortium site for the past two years, 2) becoming a "Center of Excellence" for Affymetrix technology, 3) development of the consortium web portal (arrayconsortium.tgen.org) for tutorials, transparent work-flow management and progress monitoring, role dependent information access, and data dissemination, 4)确保迈阿密的符合数据并构建用于HIPAA兼容数据共享的第一个MAGE-ML翻译引擎，5）在表达技术方面进行良好的分析（Jeffrey Trent博士参与了开发阵列技术和使用Affymetrix技术在过去七年中使用Affymetrix技术的PI，6）在2635 Affymetrix Arnay Arnay Ensertium中进行了两次运作，并在其第一个及其阵列的运作中，并在其第一个在Countration中进行了两次在其中的运作，并在其中的运作中的两年中的运作，并在其第一个andioum in and Nore the Comptium in twe Calsortium在其中的运作，并在其范围内的运作，并在其范围内进行了两次，并在其范围内进行了两年的运作。拥有商业基础设施，以及8）Stephan博士在整个3年的存在中担任该财团的主席。我们建议继续运营我们的NINDS NIMH微阵列中心。提出的结构/功能锚定在经验中，除了提案的研发部分。目标包括：1）通过Web的教程和项目提交，2）由内部审查委员会凭借神经科学经验的审查，3）整个财团的服务标准化定价，4）关于Affymetrix库存芯片和分析的数据生成，5）数据仓库，并向公众进行6个月定时释放，以及6）技术开发。