CORE--Morphology/Imaging Core

CORE--形态/成像核心

• 批准号: 6797534
• 负责人: Theresa Torres Pizarro
• 金额: $ 21.55万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797534
• 关键词: bioimaging /biomedical imaging; biomedical facility; confocal scanning microscopy; electron microscopy; gastrointestinal imaging /visualization; gastrointestinal neoplasms; gastrointestinal system; histology; imaging /visualization /scanning; immunocytochemistry; inflammation; laboratory mouse; laboratory rat; liver; morphology

The overall objective of the Morphology/Imaging Core is to provide high quality morphologic analyses of the gastrointestinal and liver systems in experimental animal models, as well as in human GI- and liver-related pathologies, from a subcellular to whole animal level. In addition, one of the major goals of the Morphology/Imaging Core is to support new and established investigators without a direct focus on digestive health research to enter this exciting field of investigation and to encourage collaborations between these groups. The Morphology/imaging Core is committed to provide basic and fundamental histologic and immunohistochemical methodologies, essential to GI-related research, while at the same time implementing state-of-the-art technology in small animal imaging as well as electron/confocal microscopy. The facilities of the Morphology/Imaging Core are located in close proximity of the two other Scientific Cores of the DHRC, which promotes a high level of interaction and collaboration between Center members. The specific aims proposed for this Core are: 1) To provide basic, quality-controlled histologic and immunohistochemical services in a cost-effect and timely fashion, 2) To provide initial service, consultation and subsequent training for special immunohistochemical staining in gastrointestinal and liver tissues, 3) To provide consistent and validated histological scoring of gastrointestinal and liver pathologies for preclinical and clinical studies performed by Center investigators, 4) To provide access at a discounted rate to state-of-the-art confocal and electron microscopy through a consulting agreement with the Center for Advanced Microscopy, 5) To provide access to cutting-edge technologies for in vivo small animal imaging to precisely address the extent and severity of disease in liver and GI tissues, and occurrence of lesions in animal models of gastrointestinal cancer and inflammation, and 6) To provide consultation and training in all aspects of GI-related morphology/imaging techniques. Therefore, the Morphology/imaging Core will provide high quality morphologic services to Center members, in a time-efficient as well as cost-effective manner, in order to enhance research and foster collaborative efforts in the investigation of gastrointestinal and liver investigation.

形态学/成像核心的总体目标是为实验动物模型以及人类胃肠道和肝脏相关病理学中的胃肠道和肝脏系统提供从亚细胞到整个动物水平的高质量形态学分析。此外，形态学/成像核心的主要目标之一是支持不直接关注消化健康研究的新的和已建立的研究人员进入这一令人兴奋的研究领域，并鼓励这些小组之间的合作。形态学/成像核心致力于提供基础的组织学和免疫组织化学方法，这对胃肠道相关研究至关重要，同时实施 小动物成像以及电子/共聚焦显微镜方面最先进的技术。形态学/成像核心的设施位于 DHRC 的另外两个科学核心附近，这促进了中心成员之间的高水平互动和协作。该核心提出的具体目标是：1）以成本效益和及时的方式提供基本的、质量控制的组织学和免疫组织化学服务，2）为胃肠道和肝脏的特殊免疫组织化学染色提供初始服务、咨询和后续培训组织，3) 为中心研究人员进行的临床前和临床研究提供一致且经过验证的胃肠道和肝脏病理学组织学评分，4) 以折扣价提供最先进的技术通过与高级显微镜中心的咨询协议，共焦和电子显微镜，5) 提供体内小动物成像的尖端技术，以精确地 解决肝脏和胃肠道组织疾病的范围和严重性，以及胃肠道癌症和炎症动物模型中病变的发生，以及 6) 提供胃肠道相关形态/成像技术各个方面的咨询和培训。因此，形态学/影像核心将以省时且经济的方式为中心成员提供高质量的形态学服务，以加强胃肠道和肝脏研究方面的研究并促进合作。