Genetic Dissection of Locomotor Senescence in Drosophila

果蝇运动衰老的遗传解析

• 批准号: 7094485
• 负责人: MICHAEL S. GROTEWIEL
• 金额: $ 18.33万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094485
• 关键词: Drosophilidae; aging; arthropod genetics; bioassay; diet; flying; functional ability; gene targeting; genetic mapping; genetically modified animals; high throughput technology; longevity; olfactions; polymerase chain reaction; reproduction; stress management; thermoreception; transposon /insertion element

DESCRIPTION (provided by applicant): The long-term goal of this project is to understand the genetic pathways that influence functional senescence using the fruit fly, Drosophila melanogaster, as a model. Although a number of genes involved in life span determination have been identified, our understanding of genes that regulate age-related functional declines is limited. Thus, the processes that govern health span remain largely uncharacterized. During the proposed funding period, my laboratory will pursue the molecular mechanisms underlying altered functional senescence in a series of recently identified Drosophila mutants. We will also begin a systematic exploration of mechanistic connections between control of life span and control of health span. These studies will help us to understand the molecular processes that underlie functional senescence and potentially life span determination. These studies will help determine how we age. They should lead to information that will help us reduce the negative effects of aging in people.

描述（由申请人提供）：该项目的长期目标是了解使用果蝇（果蝇果蝇（Drosophila Melanogaster））作为模型影响功能衰老的遗传途径。尽管已经确定了生命周期中涉及的许多基因，但我们对调节年龄相关功能下降的基因的理解是有限的。因此，控制健康跨度的过程在很大程度上没有表现。在拟议的资金期间，我的实验室将追求一系列最近确定的果蝇突变体中功能衰老改变的分子机制。我们还将开始系统地探索对寿命跨度的控制与健康跨度控制之间的机械联系。这些研究将帮助我们了解功能性衰老和潜在寿命确定的分子过程。这些研究将有助于确定我们的年龄。他们应该提供信息，以帮助我们减少人们衰老的负面影响。