Deep eutectic solvents as reaction media for chemoenzymatic cascades in continuous flow

低共熔溶剂作为连续流中化学酶级联的反应介质

• 批准号: 2746474
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746474
• 关键词: Deep; eutectic; solvents; reaction; media

Solvents tend to dominate the mass balance of manufacturing processes for fine chemicals and a large portion of their use is dedicated to intensive purification procedures. One of the major advantages of flow chemistry is the ability to perform multistep synthesis in a single continuous process which eliminates the need to purify intermediates. The combination of chemical catalysis and enzymatic catalysis in continuous flow has potential to realise unique processes for complex molecules and will be a key contributor for industry meeting net zero challenges. However, seamlessly telescoping these two forms of catalysis is difficult due to their divergent reaction conditions as chemical catalysis is typically performed in organic solvents and enzymatic catalysis often requires an aqueous environment. Deep eutectic solvents (DES) have arisen as reaction media that is mutually compatible with both chemo- and bio-catalysis and may enable new chemoenzymatic cascades to be developed in continuous flow. Additionally, DES are immiscible with most organic solvents which can be used to extract the products from the reaction mixture and allow the DES to be recycled in future reactions. This project focuses on the application of DES to facilitate chemoenzymatic cascades in continuous flow and will explore the use of inline purification technology such as liquid-liquid separators to recycle the DES throughout the process. It is envisaged the combination of multistep continuous flow synthesis and solvent recycling will lead to more sustainable processes for complex products.

溶剂倾向于主导精细化学品的制造过程的质量平衡，其大部分使用是致力于密集的纯化程序。流动化学的主要优点之一是能够在单个连续过程中执行多步合成，从而消除了净化中间体的需求。连续流中化学催化和酶促催化的结合有可能实现复杂分子的独特过程，并将成为遇到净零挑战的行业的关键因素。然而，由于反应条件的不同反应条件，由于它们通常在有机溶剂中进行化学催化，因此很难无缝伸缩这两种形式的催化，并且酶促催化通常需要水性环境。深层溶剂（DES）作为反应培养基，与化学和生物催化均相互兼容，并且可以使新的化学酶级联反应能够在连续流中发展。此外，DES与大多数有机溶剂不混溶，可用于从反应混合物中提取产物，并允许将DES在未来的反应中回收。该项目的重点是DES在连续流中促进化学酶级联反应的应用，并将探索使用液体液体分离器等内联纯化技术在整个过程中回收DES的使用。可以预见，多步骤连续流合成和溶剂回收的结合将导致复杂产品的更可持续的过程。