Functional & Cognitive Impact of HIV in Spanish Speakers

功能性

• 批准号: 6999732
• 负责人: MARIANA CHERNER
• 金额: $ 30.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999732
• 关键词: AIDS dementia complex; HIV infections; Hispanic Americans; behavioral /social science research tag; clinical research; cognition disorders; functional ability; human subject; memory; multilingualism; neuropsychological tests; neuropsychology; vehicular accident

DESCRIPTION (provided by applicant): HIV infection can be associated with neurobehavioral deficits that range in severity from subtle to marked. We and others have documented in English-speaking HIV+ individuals that these deficits, detected with traditional neuropsychological measures, are related to performance on laboratory measures of everyday functioning, such as cooking, financial management, medication management, vocational functioning, and driving abilities. We propose to extend this work to accommodate the growing numbers of HIV+ Hispanics who are primarily Spanish speaking, and for whom assessment measures and research attention remain largely undeveloped. To this end, we have adapted and translated most components of the functional battery of tests that was utilized in the project "Functional Impact of Neurobehavioral Impairments in HIV," taking care to include only instruments that are culturally relevant and likely to be ecologically valid for this population. The primary objective of the proposed project is to establish the utility of this functional battery for measuring HIV-related functional impairments in Spanish speakers. Specifically, we plan to (1) establish equivalency between our existing English language functional battery and a newly translated Spanish language version, (2) establish the internal consistency and test-retest reliability of the Spanish language functional impact battery, and (3) begin to establish the validity of the battery by demonstrating relationships in HIV+ Spanish speakers between laboratory functional assessments and both neuropsychological status and "real world" functioning.

描述（由申请人提供）：HIV 感染可能与神经行为缺陷相关，其严重程度从轻微到明显不等。我们和其他人在说英语的艾滋病毒+个体中记录了这些缺陷，通过传统的神经心理学测量发现，与日常功能的实验室测量表现有关，例如烹饪、财务管理、药物管理、职业功能和驾驶能力。我们建议扩大这项工作，以适应越来越多的艾滋病毒+西班牙裔人，他们主要讲西班牙语，而对他们来说，评估措施和研究注意力在很大程度上尚未制定。为此，我们改编并翻译了“艾滋病毒神经行为损伤的功能影响”项目中使用的功能测试组的大部分组成部分，并注意仅包含与文化相关且可能对生态有效的工具。这个人口。 拟议项目的主要目标是确定该功能电池在测量西班牙语使用者中与艾滋病毒相关的功能障碍的效用。具体来说，我们计划（1）在我们现有的英语功能电池和新翻译的西班牙语版本之间建立等效性，（2）建立西班牙语功能冲击电池的内部一致性和重测可靠性，以及（3）开始通过证明 HIV+ 西班牙语使用者的实验室功能评估与神经心理学状态和“现实世界”功能之间的关系来确定电池的有效性。